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Gene Review

lis-1  -  Protein LIS-1

Caenorhabditis elegans

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Disease relevance of lis-1


High impact information on lis-1

  • Crosses between pnm-1 and fluorescent marker strains designed to exclusively illuminate either the processes of GABAergic neurons or synaptic vesicles surprisingly showed no deviations in neuronal architecture [1].
  • lis-1 is required for dynein-dependent cell division processes in C. elegans embryos [3].
  • We identified apparent null alleles of lis-1, which result in defects identical to those observed after inactivation of the dynein heavy chain dhc-1, including defects in centrosome separation and spindle assembly [3].


  1. Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. Williams, S.N., Locke, C.J., Braden, A.L., Caldwell, K.A., Caldwell, G.A. Hum. Mol. Genet. (2004) [Pubmed]
  2. Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dawe, A.L., Caldwell, K.A., Harris, P.M., Morris, N.R., Caldwell, G.A. Dev. Genes Evol. (2001) [Pubmed]
  3. lis-1 is required for dynein-dependent cell division processes in C. elegans embryos. Cockell, M.M., Baumer, K., Gönczy, P. J. Cell. Sci. (2004) [Pubmed]
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