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Gene Review

Msh5  -  mutS homolog 5 (E. coli)

Mus musculus

Synonyms: G7, Mut5, MutS protein homolog 5
 
 
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Disease relevance of Msh5

  • Here we demonstrate that mice carrying a disruption in MutS homolog Msh5 show a meiotic defect, leading to male and female sterility [1].
 

High impact information on Msh5

 

Biological context of Msh5

  • Mice with mutations in Mlh1, Pms2 and Msh5 have defects in meiosis suggesting unique roles for these genes in gametogenesis [5].
  • Sequence and structural analyses show that the mouse gene Msh5 spans approximately 18 kb and contains 24 exons that range in length from 36 bp for exon 7 to 392 bp for exon 1 [6].
  • We have identified and characterized the complete cDNA and gene for the mouse MutS homolog 5 (Msh5), as a step toward understanding the molecular genetic mechanisms involved in the biological function of this new MutS homologous protein in mammals [6].
  • The Msh5 cDNA contains a 2502-bp open reading frame (ORF) that encodes an 833-amino acid protein with a predicted molecular weight of 92.6 kDa, which shares 89.8% amino acid sequence identity with the human hMSH5 protein [6].
 

Anatomical context of Msh5

  • Northern blot analysis demonstrated the presence of a Msh5 mRNA approximately 2.9-kb in length, most abundantly expressed in mouse testis [6].

References

  1. Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. de Vries, S.S., Baart, E.B., Dekker, M., Siezen, A., de Rooij, D.G., de Boer, P., te Riele, H. Genes Dev. (1999) [Pubmed]
  2. Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Edelmann, W., Cohen, P.E., Kneitz, B., Winand, N., Lia, M., Heyer, J., Kolodner, R., Pollard, J.W., Kucherlapati, R. Nat. Genet. (1999) [Pubmed]
  3. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Gupta, S., Aragona, E., Vemuru, R.P., Bhargava, K.K., Burk, R.D., Chowdhury, J.R. Hepatology (1991) [Pubmed]
  4. Molecular analysis of the major MHC recombinational hot spot located within the G7c gene of the murine class III region that is involved in disease susceptibility. Snoek, M., Teuscher, C., van Vugt, H. J. Immunol. (1998) [Pubmed]
  5. Mouse models for colorectal cancer. Heyer, J., Yang, K., Lipkin, M., Edelmann, W., Kucherlapati, R. Oncogene (1999) [Pubmed]
  6. Identification and characterization of the mouse MutS homolog 5: Msh5. Her, C., Wu, X., Wan, W., Doggett, N.A. Mamm. Genome (1999) [Pubmed]
 
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