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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Gametogenesis

  • In the stronger allele (110 bp insert) RPS3 mRNA levels are reduced by approximately 60%, resulting in an extreme Minute phenotype that includes many morphological abnormalities as well as sterility in both males and females due to disruption of early gametogenesis [1].
  • Administration of gold chloride at a dose of 0.3 mg/ kg body weight for 26 days led to insignificant changes of testicular Delta5-3beta-HSD,17beta-HSD activities and gametogenesis along with plasma T [2].

High impact information on Gametogenesis

  • Cis-acting regulatory elements that control imprinting are not fully understood but involve regions that become differentially methylated on the two parental chromosomes during male and female gametogenesis [3].
  • Role of Ahch in gonadal development and gametogenesis [4].
  • Here we demonstrate that male gametogenesis is severely disrupted in Atm-deficient mice in the earliest stages of meiotic prophase I, resulting in apoptotic degeneration [5].
  • Assembly of Rad51 foci on axial elements remained defective, and gametogenesis proceeded only to pachytene of prophase I [5].
  • Homozygous male and female mice also had compromised gametogenesis, leading to markedly impaired fertility, a characteristic of FA patients [6].

Biological context of Gametogenesis


Anatomical context of Gametogenesis


Associations of Gametogenesis with chemical compounds


Gene context of Gametogenesis


Analytical, diagnostic and therapeutic context of Gametogenesis


  1. Ribosomal protein insufficiency and the minute syndrome in Drosophila: a dose-response relationship. Saebøe-Larssen, S., Lyamouri, M., Merriam, J., Oksvold, M.P., Lambertsson, A. Genetics (1998) [Pubmed]
  2. Effects of gold on testicular steroidogenic and gametogenic functions in immature male albino rats. Biswas, N.M., Chattopadhyay, A., Sarkar, M. Life Sci. (2004) [Pubmed]
  3. Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Lin, S.P., Youngson, N., Takada, S., Seitz, H., Reik, W., Paulsen, M., Cavaille, J., Ferguson-Smith, A.C. Nat. Genet. (2003) [Pubmed]
  4. Role of Ahch in gonadal development and gametogenesis. Yu, R.N., Ito, M., Saunders, T.L., Camper, S.A., Jameson, J.L. Nat. Genet. (1998) [Pubmed]
  5. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles. Barlow, C., Liyanage, M., Moens, P.B., Deng, C.X., Ried, T., Wynshaw-Boris, A. Nat. Genet. (1997) [Pubmed]
  6. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Chen, M., Tomkins, D.J., Auerbach, W., McKerlie, C., Youssoufian, H., Liu, L., Gan, O., Carreau, M., Auerbach, A., Groves, T., Guidos, C.J., Freedman, M.H., Cross, J., Percy, D.H., Dick, J.E., Joyner, A.L., Buchwald, M. Nat. Genet. (1996) [Pubmed]
  7. Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors. Ray, P., Higgins, K.M., Tan, J.C., Chu, T.Y., Yee, N.S., Nguyen, H., Lacy, E., Besmer, P. Genes Dev. (1991) [Pubmed]
  8. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Feldman, N., Gerson, A., Fang, J., Li, E., Zhang, Y., Shinkai, Y., Cedar, H., Bergman, Y. Nat. Cell Biol. (2006) [Pubmed]
  9. Nup154, a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene. Gigliotti, S., Callaini, G., Andone, S., Riparbelli, M.G., Pernas-Alonso, R., Hoffmann, G., Graziani, F., Malva, C. J. Cell Biol. (1998) [Pubmed]
  10. Absence of the prion protein homologue Doppel causes male sterility. Behrens, A., Genoud, N., Naumann, H., Rülicke, T., Janett, F., Heppner, F.L., Ledermann, B., Aguzzi, A. EMBO J. (2002) [Pubmed]
  11. The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development. Mével-Ninio, M., Terracol, R., Kafatos, F.C. EMBO J. (1991) [Pubmed]
  12. Biallelic expression of imprinted genes in the mouse germ line: implications for erasure, establishment, and mechanisms of genomic imprinting. Szabó, P.E., Mann, J.R. Genes Dev. (1995) [Pubmed]
  13. Embryonic poly(A)-binding protein stimulates translation in germ cells. Wilkie, G.S., Gautier, P., Lawson, D., Gray, N.K. Mol. Cell. Biol. (2005) [Pubmed]
  14. Transcription of meiotic cell cycle and terminal differentiation genes depends on a conserved chromatin associated protein, whose nuclear localisation is regulated. White-Cooper, H., Leroy, D., MacQueen, A., Fuller, M.T. Development (2000) [Pubmed]
  15. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Robles, R., Morita, Y., Mann, K.K., Perez, G.I., Yang, S., Matikainen, T., Sherr, D.H., Tilly, J.L. Endocrinology (2000) [Pubmed]
  16. Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha. Delbès, G., Levacher, C., Duquenne, C., Racine, C., Pakarinen, P., Habert, R. Endocrinology (2005) [Pubmed]
  17. The mat-1 gene in Chlamydomonas regulates DNA methylation during gametogenesis. Sager, R., Grabowy, C., Sano, H. Cell (1981) [Pubmed]
  18. The neural basis of puberty and adolescence. Sisk, C.L., Foster, D.L. Nat. Neurosci. (2004) [Pubmed]
  19. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. Kissel, H., Timokhina, I., Hardy, M.P., Rothschild, G., Tajima, Y., Soares, V., Angeles, M., Whitlow, S.R., Manova, K., Besmer, P. EMBO J. (2000) [Pubmed]
  20. Imprinted segments in the human genome: different DNA methylation patterns in the Prader-Willi/Angelman syndrome region as determined by the genomic sequencing method. Zeschnigk, M., Schmitz, B., Dittrich, B., Buiting, K., Horsthemke, B., Doerfler, W. Hum. Mol. Genet. (1997) [Pubmed]
  21. Xanthurenic acid induces gametogenesis in Plasmodium, the malaria parasite. Garcia, G.E., Wirtz, R.A., Barr, J.R., Woolfitt, A., Rosenberg, R. J. Biol. Chem. (1998) [Pubmed]
  22. Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression. Chang, Y., Ostling, P., Akerfelt, M., Trouillet, D., Rallu, M., Gitton, Y., El Fatimy, R., Fardeau, V., Le Crom, S., Morange, M., Sistonen, L., Mezger, V. Genes Dev. (2006) [Pubmed]
  23. Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Chu, S., Herskowitz, I. Mol. Cell (1998) [Pubmed]
  24. The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells. Collier, B., Gorgoni, B., Loveridge, C., Cooke, H.J., Gray, N.K. EMBO J. (2005) [Pubmed]
  25. Coexpression of flt-3 ligand/flt-3 and SCF/c-kit signal transduction system in bile-duct-ligated SI and W mice. Omori, M., Omori, N., Evarts, R.P., Teramoto, T., Thorgeirsson, S.S. Am. J. Pathol. (1997) [Pubmed]
  26. Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice. Xia, Y., Sidis, Y., Schneyer, A. Mol. Endocrinol. (2004) [Pubmed]
  27. The trophinin gene encodes a novel group of MAGE proteins, magphinins, and regulates cell proliferation during gametogenesis in the mouse. Saburi, S., Nadano, D., Akama, T.O., Hirama, K., Yamanouchi, K., Naito, K., Tojo, H., Tachi, C., Fukuda, M.N. J. Biol. Chem. (2001) [Pubmed]
  28. Differential expression and functions of cortical myosin IIA and IIB isotypes during meiotic maturation, fertilization, and mitosis in mouse oocytes and embryos. Simerly, C., Nowak, G., de Lanerolle, P., Schatten, G. Mol. Biol. Cell (1998) [Pubmed]
  29. Characterization and expression analysis during embryo development of the mouse ortholog of MLL3. Brun, M.E., Gasca, S., Girard, C., Bouton, K., De Massy, B., De Sario, A. Gene (2006) [Pubmed]
  30. Cellular location and temporal expression of the Plasmodium falciparum sexual stage antigen Pfs16. Bruce, M.C., Carter, R.N., Nakamura, K., Aikawa, M., Carter, R. Mol. Biochem. Parasitol. (1994) [Pubmed]
  31. Developmental expression of ASG- 1 during gametogenesis in apomictic guinea grass (Panicum maximum). Chen, L., Guan, L., Seo, M., Hoffmann, F., Adachi, T. J. Plant Physiol. (2005) [Pubmed]
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