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Gene Review

pcn-1  -  Protein PCN-1

Caenorhabditis elegans

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High impact information on cyclin

  • This implies that the proper regulation of a cyclin E-Cdk complex by cki-2 is required for the elimination of the centrosome that occurs before or during oogenesis to ensure the assembly of a bipolar spindle in the C. elegans zygote [1].
  • The meiotic exit and polarity defects are separable, as inactivation of the B-type cyclin CYB-3 in pam-1 mutants rescues the meiotic exit delay but not the polarity defects [2].
  • This review focuses on the in vivo roles of cyclin-dependent kinases in C. elegans, and highlights novel findings implicating CDKs in coupling development to cell-cycle progression [3].


  1. Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans. Kim, D.Y., Roy, R. J. Cell Biol. (2006) [Pubmed]
  2. The puromycin-sensitive aminopeptidase PAM-1 is required for meiotic exit and anteroposterior polarity in the one-cell Caenorhabditis elegans embryo. Lyczak, R., Zweier, L., Group, T., Murrow, M.A., Snyder, C., Kulovitz, L., Beatty, A., Smith, K., Bowerman, B. Development (2006) [Pubmed]
  3. Cyclin-dependent kinases in C. elegans. Boxem, M. Cell division [electronic resource]. (2006) [Pubmed]
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