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Gene Review

PCNA1  -  proliferating cellular nuclear antigen 1

Arabidopsis thaliana

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High impact information on PCNA1

  • An earlier study identified two E2F consensus binding sites in the promoter of a Nicotiana benthamiana gene encoding proliferating cell nuclear antigen (PCNA) and showed that the proximal element (E2F2) is required for the full repression of PCNA expression in mature leaves [1].
  • The proliferating cell nuclear antigen (PCNA) functions as a sliding clamp for DNA polymerase, and is thus a key actor in DNA replication [2].
  • Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis [2].

Biological context of PCNA1

  • Potential E2F binding sites found in the rice PCNA promoters mediated transcriptional activation in actively dividing cells and tissues of tobacco, but not transcriptional repression in terminally differentiated tissues, as also observed for the PCF binding sites previously found in the rice promoter [3].


  1. Two E2F elements regulate the proliferating cell nuclear antigen promoter differently during leaf development. Egelkrout, E.M., Mariconti, L., Settlage, S.B., Cella, R., Robertson, D., Hanley-Bowdoin, L. Plant Cell (2002) [Pubmed]
  2. Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis. Raynaud, C., Sozzani, R., Glab, N., Domenichini, S., Perennes, C., Cella, R., Kondorosi, E., Bergounioux, C. Plant J. (2006) [Pubmed]
  3. E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters. Kosugi, S., Ohashi, Y. Plant J. (2002) [Pubmed]
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