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Gene Review

pcna  -  proliferating cell nuclear antigen

Danio rerio

Synonyms: PCNA, Proliferating cell nuclear antigen, SO:0000704, cb16, fa28e03, ...
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Disease relevance of pcna


High impact information on pcna


Biological context of pcna

  • Evaluation of cell proliferation was performed in proliferating cell nuclear antigen (PCNA)-labeled tissue sections as well as in single-cell suspensions analyzed by flow cytometry [6].
  • We investigated the expression of proliferative cell nuclear antigen (PCNA) in zebrafish to delineate the proliferative hematopoietic component during adult and embryonic hematopoiesis [5].
  • Specifically, the ef1-a:EGFP transgene colabels with PCNA in the M??ller glia, a specialized cell that is the source of neuronal progenitors during zebrafish retinal regeneration [7].
  • Furthermore, PCNA was found to be present in nuclei of oogonia and oocytes in meiotic prophase [8].
  • Triple uki/dre/lep mutants show neither an additive increase in PCNA expression nor enhanced embryonic phenotypes, suggesting that other negative regulators, possibly Ptc1, prevent further activation of the Hh signaling pathway [9].

Anatomical context of pcna


Other interactions of pcna

  • Additionally, double-immunolabel preparations for visualizing TH cells and cells containing the proliferating cell nuclear antigen (PCNA cells) were carried out allowing for a prosomeric interpretation of early forebrain TH cell clusters [10].
  • This fact as well as comparisons with PCNA- and Hu-immunostains indicate that a great proportion of ngn1-positive cells are mitotic, but some appear to extend into the postmitotic gray matter where the nrd-domains lie [11].


  1. Lens opacity and photoreceptor degeneration in the zebrafish lens opaque mutant. Vihtelic, T.S., Yamamoto, Y., Springer, S.S., Jeffery, W.R., Hyde, D.R. Dev. Dyn. (2005) [Pubmed]
  2. Secondary neurogenesis in the brain of the African clawed frog, Xenopus laevis, as revealed by PCNA, Delta-1, Neurogenin-related-1, and NeuroD expression. Wullimann, M.F., Rink, E., Vernier, P., Schlosser, G. J. Comp. Neurol. (2005) [Pubmed]
  3. Light-induced rod and cone cell death and regeneration in the adult albino zebrafish (Danio rerio) retina. Vihtelic, T.S., Hyde, D.R. J. Neurobiol. (2000) [Pubmed]
  4. Retinal regional differences in photoreceptor cell death and regeneration in light-lesioned albino zebrafish. Vihtelic, T.S., Soverly, J.E., Kassen, S.C., Hyde, D.R. Exp. Eye Res. (2006) [Pubmed]
  5. Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis. Leung, A.Y., Leung, J.C., Chan, L.Y., Ma, E.S., Kwan, T.T., Lai, K.N., Meng, A., Liang, R. Histochem. Cell Biol. (2005) [Pubmed]
  6. Quantitative evaluation of the distribution of proliferating cells in the adult retina in three cyprinid species. Cid, E., Velasco, A., Ciudad, J., Orfao, A., Aijón, J., Lara, J.M. Cell Tissue Res. (2002) [Pubmed]
  7. Two different transgenes to study gene silencing and re-expression during zebrafish caudal fin and retinal regeneration. Thummel, R., Burket, C.T., Hyde, D.R. ScientificWorldJournal (2006) [Pubmed]
  8. PCNA in the ovary of zebrafish (Brachydanio rerio, Ham.-Buch.). Korfsmeier, K.H. Acta Histochem. (2002) [Pubmed]
  9. The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway. Koudijs, M.J., den Broeder, M.J., Keijser, A., Wienholds, E., Houwing, S., van Rooijen, E.M., Geisler, R., van Eeden, F.J. PLoS Genet. (2005) [Pubmed]
  10. Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study. Rink, E., Wullimann, M.F. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  11. Anatomy of neurogenesis in the early zebrafish brain. Mueller, T., Wullimann, M.F. Brain Res. Dev. Brain Res. (2003) [Pubmed]
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