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MeSH Review

Behavior, Animal

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Psychiatry related information on Behavior, Animal


High impact information on Behavior, Animal

  • The use-dependent modification of synapses is strongly influenced by dopamine, a transmitter that participates in both the physiology and pathophysiology of animal behavior [3].
  • Recently we have produced GAD65 -/- mice and demonstrated that lack of GAD65 does not change brain GABA contents or animal behavior, except for a slight increase in susceptibility to seizures [4].
  • Infusion of PGD2 into the lateral ventricle at 15-2250 pmol/min induced natural sleep as identified by electroencephalogram, electromyogram, electrooculogram, body temperature, heart rate, and animal behavior [5].
  • Since its first characterization as a model for the detection of antidepressant drugs (van Riezen et al., 1976) a large body of data now supports the view that olfactory bulbectomy produces changes in animal behavior that are reversed by chronic treatment with antidepressants [6].
  • Experiments were designed to demonstrate the efficacy of tolvaptan reducing mortality in an acute model, and controlling the extent of serum sodium elevation without causing abnormal animal behavior suggesting neurological symptoms in a chronic model [7].

Chemical compound and disease context of Behavior, Animal

  • These two actions of p-OHA might, together with possible 5-HT efflux into the synaptic cleft, greatly contribute to head twitch, a brain 5-HT-mediated animal behavior induced by p-OHA [8].
  • Animal behavior studies have also examined the potential neurochemical mechanisms underlying the antidepressant effects of buspirone and related compounds [9].
  • Compound 8q demonstrated in vivo proof of concept in an animal behavior model where known antipsychotics are active, supporting the development of new antipsychotics based on the NMDA hypofunction model for schizophrenia [10].
  • These results represent the first demonstration of antagonist-like actions of a neuroactive steroid on the GRCs at levels ranging from the receptor to animal behavior and suggest the existence of partial agonist neurosteroids [11].
  • Indeed, nicotine-treated animals scored consistently higher on the BBB scale indicating that the treatment altered animal behavior [12].

Anatomical context of Behavior, Animal

  • The studies included evaluating whole animal behavior, electrochemical recordings of striatal dopamine release, neurochemical determinations of basal ganglia and nigral monoamine levels, and immunohistochemical staining of the nigrostriatal dopamine system [13].

Gene context of Behavior, Animal

  • Hence ICV administration of BDNF has entirely different effects on animal behavior from those evoked by NGF [14].
  • The present results also indicate the importance of the methyl group to selective MAO-A inhibition by the substrate-analogues tested, and the concomitantly induced animal behavior [15].
  • Calcineurin in animal behavior [16].
  • It was hoped that this approach may provide an alternative means of studying the role of 5-HT3 receptors on animal behavior, for the majority of related studies have used antagonists at this subtype [17].
  • The effects of prolactin on animal behavior include the stimulation of novelty-induced grooming in rats [18].


  1. Central beta-endorphin system involvement in the reaction to acute tonic pain. Porro, C.A., Tassinari, G., Facchinetti, F., Panerai, A.E., Carli, G. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1991) [Pubmed]
  2. Evolution of sleep and wakefulness organization in Macaca mulatta during Spacelab flight simulation. Balzamo, E. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (1997) [Pubmed]
  3. Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Smith, W.B., Starck, S.R., Roberts, R.W., Schuman, E.M. Neuron (2005) [Pubmed]
  4. Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Asada, H., Kawamura, Y., Maruyama, K., Kume, H., Ding, R.G., Kanbara, N., Kuzume, H., Sanbo, M., Yagi, T., Obata, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Onoe, H., Ueno, R., Fujita, I., Nishino, H., Oomura, Y., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  6. Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats. van Riezen, H., Leonard, B.E. Pharmacol. Ther. (1990) [Pubmed]
  7. Therapeutic effects of tolvaptan, a potent, selective nonpeptide vasopressin V2 receptor antagonist, in rats with acute and chronic severe hyponatremia. Miyazaki, T., Yamamura, Y., Onogawa, T., Nakamura, S., Kinoshita, S., Nakayama, S., Fujiki, H., Mori, T. Endocrinology (2005) [Pubmed]
  8. Inhibition of brain type A monoamine oxidase and 5-hydroxytryptamine uptake by two amphetamine metabolites, p-hydroxyamphetamine and p-hydroxynorephedrine. Arai, Y., Kim, S.K., Kinemuchi, H., Tadano, T., Satoh, S.E., Satoh, N., Kisara, K. J. Neurochem. (1990) [Pubmed]
  9. Behavioral studies of serotonin receptor agonists as antidepressant drugs. Lucki, I. The Journal of clinical psychiatry. (1991) [Pubmed]
  10. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. Lindsley, C.W., Wisnoski, D.D., Leister, W.H., O'brien, J.A., Lemaire, W., Williams, D.L., Burno, M., Sur, C., Kinney, G.G., Pettibone, D.J., Tiller, P.R., Smith, S., Duggan, M.E., Hartman, G.D., Conn, P.J., Huff, J.R. J. Med. Chem. (2004) [Pubmed]
  11. Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site. Xue, B.G., Whittemore, E.R., Park, C.H., Woodward, R.M., Lan, N.C., Gee, K.W. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  12. Nicotine attenuates morphological deficits in a contusion model of spinal cord injury. Ravikumar, R., Fugaccia, I., Scheff, S.W., Geddes, J.W., Srinivasan, C., Toborek, M. J. Neurotrauma (2005) [Pubmed]
  13. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. Gash, D.M., Zhang, Z., Cass, W.A., Ovadia, A., Simmerman, L., Martin, D., Russell, D., Collins, F., Hoffer, B.J., Gerhardt, G.A. J. Comp. Neurol. (1995) [Pubmed]
  14. Intraventricular injection of NGF, but not BDNF, induces rapid motor activation that is inhibited by nicotinic receptor antagonists. Kobayashi, S., Ogren, S.O., Ebendal, T., Olson, L. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1997) [Pubmed]
  15. alpha-Methylated tryptamine derivatives induce a 5-HT receptor-mediated head-twitch response in mice. Tadano, T., Neda, M., Hozumi, M., Yonezawa, A., Arai, Y., Fujita, T., Kinemuchi, H., Kisara, K. Neuropharmacology (1995) [Pubmed]
  16. Calcineurin in animal behavior. Lee, J.I., Ahnn, J. Mol. Cells (2004) [Pubmed]
  17. Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats. Higgins, G.A., Joharchi, N., Sellers, E.M. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  18. The "low-dose" concept and the paradoxical effects of prolactin on grooming and sexual behavior. Drago, F., Lissandrello, C.O. Eur. J. Pharmacol. (2000) [Pubmed]
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