The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

jnk-1  -  Protein JNK-1

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of jnk-1

  • In Caenorhabditis elegans a PMK-1 p38 MAPK pathway is required for resistance to bacterial infection, and a KGB-1 JNK-like MAPK pathway has recently been shown to mediate resistance to heavy metal stress [1].

High impact information on jnk-1

  • jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans [2].
  • The c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family, was shown to be involved in the response to various stresses in cultured cells [3].
  • Both jnk-1 and jkk-1 are expressed in most neurons. jkk-1 null mutant animals exhibit defects in locomotion that can be rescued by the conditional expression of JKK-1 in mutant adults, suggesting that the defect is not due to a developmental error [4].
  • Thus, the C.elegans JNK pathway functions in type-D GABAergic motor neurons and thereby modulates coordinated locomotion [4].

Biological context of jnk-1


Other interactions of jnk-1

  • We identified the Caenorhabditis elegans mek-1 gene, which encodes a 347 amino acid protein highly homologous to mammalian MKK7, an activator of JNK [3].


  1. Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Kim, D.H., Liberati, N.T., Mizuno, T., Inoue, H., Hisamoto, N., Matsumoto, K., Ausubel, F.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. Villanueva, A., Lozano, J., Morales, A., Lin, X., Deng, X., Hengartner, M.O., Kolesnick, R.N. EMBO J. (2001) [Pubmed]
  3. A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses. Koga, M., Zwaal, R., Guan, K.L., Avery, L., Ohshima, Y. EMBO J. (2000) [Pubmed]
  4. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. Kawasaki, M., Hisamoto, N., Iino, Y., Yamamoto, M., Ninomiya-Tsuji, J., Matsumoto, K. EMBO J. (1999) [Pubmed]
WikiGenes - Universities