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Gene Review

Mapk8  -  mitogen-activated protein kinase 8

Rattus norvegicus

Synonyms: Jnk1, MAP kinase 8, MAPK 8, Mitogen-activated protein kinase 8, Prkm8, ...
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Disease relevance of Mapk8


High impact information on Mapk8


Chemical compound and disease context of Mapk8


Biological context of Mapk8


Anatomical context of Mapk8


Associations of Mapk8 with chemical compounds


Physical interactions of Mapk8


Regulatory relationships of Mapk8


Other interactions of Mapk8


Analytical, diagnostic and therapeutic context of Mapk8


  1. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion. Bogoyevitch, M.A., Gillespie-Brown, J., Ketterman, A.J., Fuller, S.J., Ben-Levy, R., Ashworth, A., Marshall, C.J., Sugden, P.H. Circ. Res. (1996) [Pubmed]
  2. Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells. Conrad, P.W., Rust, R.T., Han, J., Millhorn, D.E., Beitner-Johnson, D. J. Biol. Chem. (1999) [Pubmed]
  3. The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK). Edwards, L., Fishman, D., Horowitz, P., Bourbon, N., Kester, M., Ernsberger, P. J. Neurochem. (2001) [Pubmed]
  4. Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. Ferrandi, C., Ballerio, R., Gaillard, P., Giachetti, C., Carboni, S., Vitte, P.A., Gotteland, J.P., Cirillo, R. Br. J. Pharmacol. (2004) [Pubmed]
  5. Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia. Clanachan, A.S., Jaswal, J.S., Gandhi, M., Bottorff, D.A., Coughlin, J., Finegan, B.A., Stone, J.C. Transplantation (2003) [Pubmed]
  6. Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95. Reinehr, R., Häussinger, D. Gastroenterology (2004) [Pubmed]
  7. Involvement of the Src family kinase yes in bile salt-induced apoptosis. Reinehr, R., Becker, S., Wettstein, M., Häussinger, D. Gastroenterology (2004) [Pubmed]
  8. Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis. Gigliozzi, A., Alpini, G., Baroni, G.S., Marucci, L., Metalli, V.D., Glaser, S.S., Francis, H., Mancino, M.G., Ueno, Y., Barbaro, B., Benedetti, A., Attili, A.F., Alvaro, D. Gastroenterology (2004) [Pubmed]
  9. Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. Reinehr, R., Graf, D., Häussinger, D. Gastroenterology (2003) [Pubmed]
  10. Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. Graf, D., Kurz, A.K., Fischer, R., Reinehr, R., Häussinger, D. Gastroenterology (2002) [Pubmed]
  11. Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway. Yoshizumi, M., Tsuchiya, K., Suzaki, Y., Kirima, K., Kyaw, M., Moon, J.H., Terao, J., Tamaki, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  12. MEKK4 mediates differentiation in response to retinoic acid via activation of c-Jun N-terminal kinase in rat embryonal carcinoma P19 cells. Kanungo, J., Potapova, I., Malbon, C.C., Wang, H. J. Biol. Chem. (2000) [Pubmed]
  13. Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells. Tseng, S.H., Wang, C.H., Lin, S.M., Chen, C.K., Huang, H.Y., Chen, Y. J. Cancer Res. Clin. Oncol. (2004) [Pubmed]
  14. Protection against malonate-induced ischemic brain injury in rat by a cell-permeable peptidic c-Jun N-terminal kinase inhibitor, (L)-HIV-TAT48-57-PP-JBD20, observed by the apparent diffusion coefficient mapping magnetic resonance imaging method. Asanuma, T., Inanami, O., Tabu, K., Waki, K., Kon, Y., Kuwabara, M. Neurosci. Lett. (2004) [Pubmed]
  15. Suppression of apoptosis by all-trans-retinoic acid. Dual intervention in the c-Jun n-terminal kinase-AP-1 pathway. Moreno-Manzano, V., Ishikawa, Y., Lucio-Cazana, J., Kitamura, M. J. Biol. Chem. (1999) [Pubmed]
  16. A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte morphology. Ng, D.C., Long, C.S., Bogoyevitch, M.A. J. Biol. Chem. (2001) [Pubmed]
  17. Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. Wang, Y., Schattenberg, J.M., Rigoli, R.M., Storz, P., Czaja, M.J. J. Biol. Chem. (2004) [Pubmed]
  18. Differential roles of JNK and Smad2 signaling pathways in the inhibition of c-Myc-induced cell death by TGF-beta. Mazars, A., Tournigand, C., Mollat, P., Prunier, C., Ferrand, N., Bourgeade, M.F., Gespach, C., Atfi, A. Oncogene (2000) [Pubmed]
  19. A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Fogarty, M.P., Downer, E.J., Campbell, V. Biochem. J. (2003) [Pubmed]
  20. Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac, and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activation. Li, J., Smithgall, T.E. J. Biol. Chem. (1998) [Pubmed]
  21. Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway. Song, J.S., Haleem-Smith, H., Arudchandran, R., Gomez, J., Scott, P.M., Mill, J.F., Tan, T.H., Rivera, J. J. Immunol. (1999) [Pubmed]
  22. Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. Ishikawa, Y., Kitamura, M. Kidney Int. (2000) [Pubmed]
  23. Variant PC12 cell line that spontaneously differentiates and extends neuritic processes. Xiao, J., Zhou, Q., Liu, Y. J. Neurosci. Res. (2002) [Pubmed]
  24. Fibroblast growth factors regulate prolactin transcription via an atypical Rac-dependent signaling pathway. Jackson, T.A., Koterwas, D.M., Morgan, M.A., Bradford, A.P. Mol. Endocrinol. (2003) [Pubmed]
  25. Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection. Chen, R.W., Qin, Z.H., Ren, M., Kanai, H., Chalecka-Franaszek, E., Leeds, P., Chuang, D.M. J. Neurochem. (2003) [Pubmed]
  26. The expression of heme oxygenase-1 gene responded to oxidative stress produced by phorone, a glutathione depletor, in the rat liver; the relevance to activation of c-jun n-terminal kinase. Oguro, T., Hayashi, M., Nakajo, S., Numazawa, S., Yoshida, T. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  27. Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells. Yoshizumi, M., Kogame, T., Suzaki, Y., Fujita, Y., Kyaw, M., Kirima, K., Ishizawa, K., Tsuchiya, K., Kagami, S., Tamaki, T. Br. J. Pharmacol. (2002) [Pubmed]
  28. The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase. Rueda, D., Galve-Roperh, I., Haro, A., Guzmán, M. Mol. Pharmacol. (2000) [Pubmed]
  29. Thyrotropin-releasing hormone-stimulated thyrotropin expression involves islet-brain-1/c-Jun N-terminal kinase interacting protein-1. Abe, H., Murao, K., Imachi, H., Cao, W.M., Yu, X., Yoshida, K., Wong, N.C., Shupnik, M.A., Haefliger, J.A., Waeber, G., Ishida, T. Endocrinology (2004) [Pubmed]
  30. 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. Chen, J., Shen, C., Meller, E. Eur. J. Pharmacol. (2002) [Pubmed]
  31. c-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle. Lee, Y.R., Lee, C.K., Park, H.J., Kim, H., Kim, J., Kim, J., Lee, K.S., Lee, Y.L., Min, K.O., Kim, B. J. Pharmacol. Sci. (2006) [Pubmed]
  32. Hypothermia differentially increases extracellular signal-regulated kinase and stress-activated protein kinase/c-Jun terminal kinase activation in the hippocampus during reperfusion after asphyxial cardiac arrest. Hicks, S.D., Parmele, K.T., DeFranco, D.B., Klann, E., Callaway, C.W. Neuroscience (2000) [Pubmed]
  33. Alteration of transforming growth factor-beta signaling system expression in adult rat germ cells with a chronic apoptotic cell death process after fetal androgen disruption. Maire, M., Florin, A., Kaszas, K., Regnier, D., Contard, P., Tabone, E., Mauduit, C., Bars, R., Benahmed, M. Endocrinology (2005) [Pubmed]
  34. Increased insulin receptor substrate 1 serine phosphorylation and stress-activated protein kinase/c-Jun N-terminal kinase activation associated with vascular insulin resistance in spontaneously hypertensive rats. Sugita, M., Sugita, H., Kaneki, M. Hypertension (2004) [Pubmed]
  35. Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures. Mielke, K., Brecht, S., Dorst, A., Herdegen, T. Neuroscience (1999) [Pubmed]
  36. Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Zhang, Z., Sheng, H., Shao, J., Beauchamp, R.D., DuBois, R.N. Neoplasia (2000) [Pubmed]
  37. Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Yoshida, K., Matsuzaki, K., Mori, S., Tahashi, Y., Yamagata, H., Furukawa, F., Seki, T., Nishizawa, M., Fujisawa, J., Okazaki, K. Am. J. Pathol. (2005) [Pubmed]
  38. Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type. Földes, G., Vajda, S., Lakó-Futó, Z., Sármán, B., Skoumal, R., Ilves, M., deChâtel, R., Karádi, I., Tóth, M., Ruskoaho, H., Leprán, I. J. Lipid Res. (2006) [Pubmed]
  39. Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug-induced apoptosis in salivary gland acinar cells. Anderson, S.M., Reyland, M.E., Hunter, S., Deisher, L.M., Barzen, K.A., Quissell, D.O. Cell Death Differ. (1999) [Pubmed]
  40. Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus. Ma, W., Quirion, R. Pain (2002) [Pubmed]
  41. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Uehara, T., Xi Peng, X., Bennett, B., Satoh, Y., Friedman, G., Currin, R., Brenner, D.A., Lemasters, J. Transplantation (2004) [Pubmed]
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