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Gene Review

tagA  -  ToxR-regulated lipoprotein

Escherichia coli O157:H7 str. Sakai

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Disease relevance of tagA

  • The region containing aldA and tagA comprises 13 kb of previously unidentified DNA and is part of a PAI that contains a regulator of virulence genes (ToxT) and a gene cluster encoding an essential colonization factor and the cholera toxin phage receptor (toxin-coregulated pilus; TCP) [1].
  • Expression of the aldA gene was studied together with that of tagA in both V. cholerae and Escherichia coli [2].
  • The Vibrio cholerae (Vc) gene (tagA) coding for the TagA lipoprotein has been isolated [3].
  • Molecular and functional characterization of a ToxR-regulated lipoprotein from a clinical isolate of Aeromonas hydrophila [4].

High impact information on tagA


Biological context of tagA

  • Each hybrid plasmid directed the synthesis of 21-kDa m3ADG in E. coli tagA- ada-, which were not inhibited by 4 mM m3A [7].
  • In all cases, the tagA mutation, which inactivates the constitutive and specific 3-alkyladenine-DNA glycosylase I (TagI), sensitizes the strain to the SOS response [8].


  1. A Vibrio cholerae pathogenicity island associated with epidemic and pandemic strains. Karaolis, D.K., Johnson, J.A., Bailey, C.C., Boedeker, E.C., Kaper, J.B., Reeves, P.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator. Parsot, C., Mekalanos, J.J. J. Bacteriol. (1991) [Pubmed]
  3. Isolation and characterization of a Vibrio cholerae gene (tagA) that encodes a ToxR-regulated lipoprotein. Harkey, C.W., Everiss, K.D., Peterson, K.M. Gene (1995) [Pubmed]
  4. Molecular and functional characterization of a ToxR-regulated lipoprotein from a clinical isolate of Aeromonas hydrophila. Pillai, L., Sha, J., Erova, T.E., Fadl, A.A., Khajanchi, B.K., Chopra, A.K. Infect. Immun. (2006) [Pubmed]
  5. 3-Methyladenine residues in DNA induce the SOS function sfiA in Escherichia coli. Boiteux, S., Huisman, O., Laval, J. EMBO J. (1984) [Pubmed]
  6. Reactivity of convalescent-phase hemolytic-uremic syndrome patient sera with the megaplasmid-encoded TagA protein of Shiga toxigenic Escherichia coli O157. Paton, A.W., Paton, J.C. J. Clin. Microbiol. (2002) [Pubmed]
  7. Cloning of Micrococcus luteus 3-methyladenine-DNA glycosylase genes in Escherichia coli. Pierre, J., Laval, J. Gene (1986) [Pubmed]
  8. Induction of SOS and adaptive responses by alkylating agents in Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase activities. Costa de Oliveira, R., Laval, J., Boiteux, S. Mutat. Res. (1987) [Pubmed]
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