Gene Review:
sem-5 - Protein SEM-5
Caenorhabditis elegans
- An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. DeVore, D.L., Horvitz, H.R., Stern, M.J. Cell (1995)
- C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Clark, S.G., Stern, M.J., Horvitz, H.R. Nature (1992)
- The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Gutch, M.J., Flint, A.J., Keller, J., Tonks, N.K., Hengartner, M.O. Genes Dev. (1998)
- ARK-1 inhibits EGFR signaling in C. elegans. Hopper, N.A., Lee, J., Sternberg, P.W. Mol. Cell (2000)
- The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5. Stern, M.J., Marengere, L.E., Daly, R.J., Lowenstein, E.J., Kokel, M., Batzer, A., Olivier, P., Pawson, T., Schlessinger, J. Mol. Biol. Cell (1993)
- Introduction of a loss-of-function point mutation from the SH3 region of the Caenorhabditis elegans sem-5 gene activates the transforming ability of c-abl in vivo and abolishes binding of proline-rich ligands in vitro. Van Etten, R.A., Debnath, J., Zhou, H., Casasnovas, J.M. Oncogene (1995)
- Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites. Chen, E.B., Branda, C.S., Stern, M.J. Dev. Biol. (1997)