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Gene Review

mes-1  -  Protein MES-1

Caenorhabditis elegans

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High impact information on mes-1

  • Genetic and molecular analyses of several genes, including six par genes and the mex-1 and mes-1 genes, together with experimental embryological studies, have provided insights into mechanisms controlling polarity and spindle orientations during these cleavages [1].
  • This paper shows that mes-1 encodes a receptor tyrosine kinase-like protein, though it lacks several residues conserved in all kinases and therefore is predicted not to have kinase activity [2].
  • These divisions produce germline blastomeres (P(1), P(2), P(3), P(4)) that differ from their somatic sisters in their size, fate and cytoplasmic content (e.g. germ granules). mes-1 mutant embryos display the striking phenotype of transformation of P(4) into a muscle precursor, like its somatic sister [2].
  • Microfilaments, microtubules and the product of the gene mes-1 are required for the normal pattern of P-granule segregation in P2 [3].
  • Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans [4].

Biological context of mes-1


Anatomical context of mes-1

  • Moreover, src-1 and mes-1 mutants strongly enhance endoderm and EMS spindle rotation defects associated with Wnt pathway mutants [7].

Associations of mes-1 with chemical compounds


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