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Gene Review

Npas2  -  neuronal PAS domain protein 2

Mus musculus

Synonyms: MOP4, Neuronal PAS domain-containing protein 2, Neuronal PAS2, bHLHe9
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High impact information on Npas2

  • MOP4 exhibits a robust rhythm in the vasculature, and retinoic acid can phase shift Per2 mRNA rhythmicity in vivo and in serum-induced smooth muscle cells in vitro, providing a molecular mechanism for hormonal control of clock gene expression [1].
  • Neuronal PAS domain protein 2 (NPAS2) is a transcription factor expressed primarily in the mammalian forebrain [2].
  • Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain [3].
  • Transient transfection experiments demonstrated that the MOP3-MOP4 and MOP3-CLOCK complexes bound this element in COS-1 cells and drove transcription from a linked luciferase reporter gene [4].
  • Neuronal PAS domain protein 2 (NPAS2) is a circadian rhythm-associated transcription factor with two heme-binding sites on two PAS domains [5].

Biological context of Npas2


Anatomical context of Npas2


Associations of Npas2 with chemical compounds


Other interactions of Npas2


  1. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. McNamara, P., Seo, S.P., Rudic, R.D., Sehgal, A., Chakravarti, D., FitzGerald, G.A. Cell (2001) [Pubmed]
  2. NPAS2: an analog of clock operative in the mammalian forebrain. Reick, M., Garcia, J.A., Dudley, C., McKnight, S.L. Science (2001) [Pubmed]
  3. Impaired cued and contextual memory in NPAS2-deficient mice. Garcia, J.A., Zhang, D., Estill, S.J., Michnoff, C., Rutter, J., Reick, M., Scott, K., Diaz-Arrastia, R., McKnight, S.L. Science (2000) [Pubmed]
  4. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Hogenesch, J.B., Gu, Y.Z., Jain, S., Bradfield, C.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Spectroscopic and DNA-binding characterization of the isolated heme-bound basic helix-loop-helix-PAS-A domain of neuronal PAS protein 2 (NPAS2), a transcription activator protein associated with circadian rhythms. Mukaiyama, Y., Uchida, T., Sato, E., Sasaki, A., Sato, Y., Igarashi, J., Kurokawa, H., Sagami, I., Kitagawa, T., Shimizu, T. FEBS J. (2006) [Pubmed]
  6. Spectroscopic characterization of the isolated heme-bound PAS-B domain of neuronal PAS domain protein 2 associated with circadian rhythms. Koudo, R., Kurokawa, H., Sato, E., Igarashi, J., Uchida, T., Sagami, I., Kitagawa, T., Shimizu, T. FEBS J. (2005) [Pubmed]
  7. Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Dudley, C.A., Erbel-Sieler, C., Estill, S.J., Reick, M., Franken, P., Pitts, S., McKnight, S.L. Science (2003) [Pubmed]
  8. Reciprocal regulation of haem biosynthesis and the circadian clock in mammals. Kaasik, K., Lee, C.C. Nature (2004) [Pubmed]
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