Gene Review:
Per2 - period circadian clock 2
Mus musculus
Synonyms:
Circadian clock protein PERIOD 2, Period circadian protein homolog 2, mKIAA0347, mPER2, mPer2
- The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock. Liu, J., Mankani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., Sun, Z.S. Infect. Immun. (2006)
- Circadian rhythm generation in a glioma cell line. Fujioka, A., Takashima, N., Shigeyoshi, Y. Biochem. Biophys. Res. Commun. (2006)
- A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. Yoo, S.H., Ko, C.H., Lowrey, P.L., Buhr, E.D., Song, E.J., Chang, S., Yoo, O.J., Yamazaki, S., Lee, C., Takahashi, J.S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1 ( Brdm1 ) mutant mice. Zghoul, T., Abarca, C., Sanchis-Segura, C., Albrecht, U., Schumann, G., Spanagel, R. Psychopharmacology (Berl.) (2007)
- Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Bae, K., Jin, X., Maywood, E.S., Hastings, M.H., Reppert, S.M., Weaver, D.R. Neuron (2001)
- Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes. Shiromani, P.J., Xu, M., Winston, E.M., Shiromani, S.N., Gerashchenko, D., Weaver, D.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004)
- Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Abarca, C., Albrecht, U., Spanagel, R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling. Jilg, A., Moek, J., Weaver, D.R., Korf, H.W., Stehle, J.H., von Gall, C. Eur. J. Neurosci. (2005)
- The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Harmar, A.J., Marston, H.M., Shen, S., Spratt, C., West, K.M., Sheward, W.J., Morrison, C.F., Dorin, J.R., Piggins, H.D., Reubi, J.C., Kelly, J.S., Maywood, E.S., Hastings, M.H. Cell (2002)
- The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Fu, L., Pelicano, H., Liu, J., Huang, P., Lee, C. Cell (2002)
- Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. McNamara, P., Seo, S.P., Rudic, R.D., Sehgal, A., Chakravarti, D., FitzGerald, G.A. Cell (2001)
- Posttranslational mechanisms regulate the mammalian circadian clock. Lee, C., Etchegaray, J.P., Cagampang, F.R., Loudon, A.S., Reppert, S.M. Cell (2001)
- The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Spanagel, R., Pendyala, G., Abarca, C., Zghoul, T., Sanchis-Segura, C., Magnone, M.C., Lascorz, J., Depner, M., Holzberg, D., Soyka, M., Schreiber, S., Matsuda, F., Lathrop, M., Schumann, G., Albrecht, U. Nat. Med. (2005)
- Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Etchegaray, J.P., Lee, C., Wade, P.A., Reppert, S.M. Nature (2003)
- Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice. Kopp, C., Albrecht, U., Zheng, B., Tobler, I. Eur. J. Neurosci. (2002)
- mPer2 antisense oligonucleotides inhibit mPER2 expression but not circadian rhythms of physiological activity in cultured suprachiasmatic nucleus neurons. Sugiyama, T., Yoshioka, T., Ikeda, M. Biochem. Biophys. Res. Commun. (2004)
- Calcium and pituitary adenylate cyclase-activating polypeptide induced expression of circadian clock gene mPer1 in the mouse cerebellar granule cell culture. Akiyama, M., Minami, Y., Nakajima, T., Moriya, T., Shibata, S. J. Neurochem. (2001)
- Differential daily expression of Per1 and Per2 mRNA in the suprachiasmatic nucleus of fetal and early postnatal mice. Shimomura, H., Moriya, T., Sudo, M., Wakamatsu, H., Akiyama, M., Miyake, Y., Shibata, S. Eur. J. Neurosci. (2001)
- Effects of altered Clock gene expression on the pacemaker properties of SCN2.2 cells and oscillatory properties of NIH/3T3 cells. Allen, G.C., Farnell, Y., Bell-Pedersen, D., Cassone, V.M., Earnest, D.J. Neuroscience (2004)
- Molecular analysis of avian circadian clock genes. Yoshimura, T., Suzuki, Y., Makino, E., Suzuki, T., Kuroiwa, A., Matsuda, Y., Namikawa, T., Ebihara, S. Brain Res. Mol. Brain Res. (2000)
- A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus. Takumi, T., Matsubara, C., Shigeyoshi, Y., Taguchi, K., Yagita, K., Maebayashi, Y., Sakakida, Y., Okumura, K., Takashima, N., Okamura, H. Genes Cells (1998)
- Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Zylka, M.J., Shearman, L.P., Weaver, D.R., Reppert, S.M. Neuron (1998)
- Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle. Mendoza, J., Graff, C., Dardente, H., Pevet, P., Challet, E. J. Neurosci. (2005)
- Modeling feedback loops of the Mammalian circadian oscillator. Becker-Weimann, S., Wolf, J., Herzel, H., Kramer, A. Biophys. J. (2004)
- Cholesterol diet enhances daily rhythm of Pai-1 mRNA in the mouse liver. Kudo, T., Nakayama, E., Suzuki, S., Akiyama, M., Shibata, S. Am. J. Physiol. Endocrinol. Metab. (2004)
- Differential regulation of two period genes in the Xenopus eye. Zhuang, M., Wang, Y., Steenhard, B.M., Besharse, J.C. Brain Res. Mol. Brain Res. (2000)
- Adrenergic regulation of clock gene expression in mouse liver. Terazono, H., Mutoh, T., Yamaguchi, S., Kobayashi, M., Akiyama, M., Udo, R., Ohdo, S., Okamura, H., Shibata, S. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Long-lived {alpha}MUPA transgenic mice exhibit pronounced circadian rhythms. Froy, O., Chapnik, N., Miskin, R. Am. J. Physiol. Endocrinol. Metab. (2006)