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Gene Review:

hch-1 - Protein HCH-1

Caenorhabditis elegans

Williamson, A.L. et al., Kubota, Y. et al., Angerer, L. et al., Hishida, R. et al., Cai, G.B. et al.

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High impact information on metalloprotease

However, the phenotype of hch-1 mutants shows that it is required for normal hatching and normal migration of a post-embryonic neuroblast [1].
Analysis of the Strongylocentrotus purpuratus genome has revealed approximately 240 metalloprotease genes, and they represent all 23 families expressed in vertebrates [2].
The metalloprotease inhibitors EDTA and 1,10-phenanthroline also reduced the penetration of L3 through skin in vitro by 43 to 61% [3].
A membrane-associated metalloprotease of Taenia solium metacestode structurally related to the FACE-1/Ste24p protease family [4].
In C. elegans, the COG complex acts in the glycosylation of an ADAM (a disintegrin and metalloprotease) family protein, MIG-17, which directs migration of gonadal distal tip cells to lead gonad morphogenesis [5].

References

hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1. Hishida, R., Ishihara, T., Kondo, K., Katsura, I. EMBO J. (1996) [Pubmed]
Sea urchin metalloproteases: A genomic survey of the BMP-1/tolloid-like, MMP and ADAM families. Angerer, L., Hussain, S., Wei, Z., Livingston, B.T. Dev. Biol. (2006) [Pubmed]
Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. Williamson, A.L., Lustigman, S., Oksov, Y., Deumic, V., Plieskatt, J., Mendez, S., Zhan, B., Bottazzi, M.E., Hotez, P.J., Loukas, A. Infect. Immun. (2006) [Pubmed]
A membrane-associated metalloprotease of Taenia solium metacestode structurally related to the FACE-1/Ste24p protease family. Cai, G.B., Bae, Y.A., Kim, S.H., Na, B.K., Kim, T.S., Jiang, M.S., Kong, Y. Int. J. Parasitol. (2006) [Pubmed]
C. elegans as a model system to study the function of the COG complex in animal development. Kubota, Y., Nishiwaki, K. Biol. Chem. (2006) [Pubmed]

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