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Chemical Compound Review

Getril     [1-butoxy-3-(5-ethyl-2,4,6- trioxo-5-phenyl...

Synonyms: Solium, Tymium, Febarbamate, Febarbamato, phenobamate, ...
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Disease relevance of GO 560

  • A diagnosis of neurocysticercosis should be considered in patients with seizures and radiologic evidence of cystic brain lesions, even in those who do not eat pork and who have not traveled to a country in which T. solium infection is endemic [1].
  • Recent emigrants from countries in which T. solium infection is endemic should be screened for tapeworm infection in their stools before they are employed as housekeepers or food handlers [1].
  • Cysticercosis was diagnosed in 12 US citizens who had no history of travel to countries considered traditionally endemic for Taenia solium taeniasis/cysticercosis [2].
  • Here, Akira Ito and Mamoru Ito review recent results demonstrating the potential of the severe combined immunodeficiency (SCID) mouse for supporting development of the larval stages of Taenia saginata asiatica, T. saginata and T. solium [3].
  • In the present study a detailed histological and immunohistochemical analysis of the immune response was performed on eight craniotomy specimens where a granuloma surrounded each T. solium metacestode [4].

Psychiatry related information on GO 560


High impact information on GO 560


Chemical compound and disease context of GO 560


Biological context of GO 560


Anatomical context of GO 560


Associations of GO 560 with other chemical compounds

  • A Taenia solium-specific glycoprotein-based electroimmunotransfer blot (EITB) assay was reported to be highly sensitive and specific for this purpose [25].
  • The characteristic thymine-base peak profiles provide four distinct types, unique for T. saginata, T. asiatica, and two genotypes of T. solium [26].
  • Purification and characterization of a metacestode cysteine proteinase from Taenia solium involved in the breakdown of human IgG [27].
  • Molecular and functional characterization and tissue localization of 2 glucose transporter homologues (TGTP1 and TGTP2) from the tapeworm Taenia solium [12].
  • The entire family agreed to undergo chemotherapy with niclosamide, but only the child passing taeniid eggs eliminated T. solium [28].

Gene context of GO 560

  • In the related species of T. solium and T. saginata, the deduced amino acid sequences of ATP6 were homogeneous; however, the conversion of initiation codon AUG into GUG was observed in T. saginata [29].
  • Genetic polymorphism was determined among 13 isolates of Taenia solium from various regions using PCR-amplified sequences of 2 mitochondrial genes: cytochrome c oxidase subunit 1 and cytochrome b [30].
  • The sequences of the cox1 genes between T. asiatica and T. saginata differ by 4.6%, while the T. asiatica cob gene differs by 4.1% and 12.9% from the cob genes of T. saginata and T. solium, respectively [31].
  • RT-PCR amplification of the parasite's total RNA, showed that T. crassiceps expressed both AP-1 complex genes, while T. solium only expressed c-fos [32].
  • Homologues of c-fos and c-jun from total DNA of Taenia crassiceps and Taenia solium were cloned and sequenced [32].

Analytical, diagnostic and therapeutic context of GO 560

  • Cases and control subjects were assessed serologically for antibodies against T. canis by ELISA and against T. solium by enzyme-linked immunoelectrotransfer blot (EITB) [33].
  • Clinical normalization was paralleled by a significant decrease (p < 0.05) in the amount of intrathecally produced anti-T solium IgG 1 year after treatment [34].
  • OBJECTIVE: To assess the relationship between epilepsy and infection with Taenia solium and Toxocara canis with a case-control study, in the rural area of the Cordillera Province, Bolivia [33].
  • This is the highest level of protection that has been achieved against T. solium infection in pigs by vaccination with a defined antigen [35].
  • Immunofluorescence studies revealed that anti-GK1 antibodies strongly react with the native protein in the tegument of T. crassiceps and also with anatomical structures of T. solium eggs, oncospheres, cysticercus, and tapeworm [36].


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