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Gene Review

adm-4  -  Protein ADM-4

Caenorhabditis elegans

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Disease relevance of metalloprotease


High impact information on metalloprotease


Biological context of metalloprotease


Anatomical context of metalloprotease


Associations of metalloprotease with chemical compounds

  • A membrane-associated metalloprotease of Taenia solium metacestode structurally related to the FACE-1/Ste24p protease family [11].
  • Microfilariae of O. cervicalis and O. cervipedis produced both a serine and a metalloprotease, but the level of protease activity of these microfilariae was substantially lower than that of L3 larvae, and no significant protease activity was detected in extracts of O. lienalis microfilariae [12].

Other interactions of metalloprotease


Analytical, diagnostic and therapeutic context of metalloprotease


  1. Purification and characterization of an extracellular protease from Xenorhabdus nematophila involved in insect immunosuppression. Caldas, C., Cherqui, A., Pereira, A., Simões, N. Appl. Environ. Microbiol. (2002) [Pubmed]
  2. Genetic and biochemical characterization of PrtA, an RTX-like metalloprotease from Photorhabdus. Bowen, D.J., Rocheleau, T.A., Grutzmacher, C.K., Meslet, L., Valens, M., Marble, D., Dowling, A., Ffrench-Constant, R., Blight, M.A. Microbiology (Reading, Engl.) (2003) [Pubmed]
  3. Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae. McKerrow, J.H., Brindley, P., Brown, M., Gam, A.A., Staunton, C., Neva, F.A. Exp. Parasitol. (1990) [Pubmed]
  4. A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans. Nishiwaki, K., Hisamoto, N., Matsumoto, K. Science (2000) [Pubmed]
  5. A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans. Davis, M.W., Birnie, A.J., Chan, A.C., Page, A.P., Jorgensen, E.M. Development (2004) [Pubmed]
  6. C. elegans as a model system to study the function of the COG complex in animal development. Kubota, Y., Nishiwaki, K. Biol. Chem. (2006) [Pubmed]
  7. The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans. Blelloch, R., Anna-Arriola, S.S., Gao, D., Li, Y., Hodgkin, J., Kimble, J. Dev. Biol. (1999) [Pubmed]
  8. Sea urchin metalloproteases: A genomic survey of the BMP-1/tolloid-like, MMP and ADAM families. Angerer, L., Hussain, S., Wei, Z., Livingston, B.T. Dev. Biol. (2006) [Pubmed]
  9. Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Cadiñanos, J., Schmidt, W.K., Fueyo, A., Varela, I., López-Otín, C., Freije, J.M. Biochem. J. (2003) [Pubmed]
  10. UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans. Huang, X., Huang, P., Robinson, M.K., Stern, M.J., Jin, Y. Development (2003) [Pubmed]
  11. A membrane-associated metalloprotease of Taenia solium metacestode structurally related to the FACE-1/Ste24p protease family. Cai, G.B., Bae, Y.A., Kim, S.H., Na, B.K., Kim, T.S., Jiang, M.S., Kong, Y. Int. J. Parasitol. (2006) [Pubmed]
  12. Extracellular proteases of Onchocerca. Lackey, A., James, E.R., Sakanari, J.A., Resnick, S.D., Brown, M., Bianco, A.E., McKerrow, J.H. Exp. Parasitol. (1989) [Pubmed]
  13. Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target. Novelli, J., Ahmed, S., Hodgkin, J. Genetics (2004) [Pubmed]
  14. Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi. De Maere, V., Vercauteren, I., Geldhof, P., Gevaert, K., Vercruysse, J., Claerebout, E. Parasitology (2005) [Pubmed]
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