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Gene Review

Ntan1  -  N-terminal Asn amidase

Mus musculus

Synonyms: PNAA, PNAD, Protein N-terminal Asn amidase, Protein N-terminal asparagine amidohydrolase, Protein NH2-terminal asparagine amidohydrolase, ...
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High impact information on Ntan1

  • Among the normally short-lived N-end rule substrates, only those bearing N-terminal asparagine became long-lived in Ntan1(-/-) fibroblasts [1].
  • In wild-type embryos, Ntan1 was strongly expressed in the branchial arches and in the tail and limb buds [1].
  • The Ntan1(-/-) mouse strains lacked the Nt(N)-amidase activity but retained glutamine-specific Nt(Q)-amidase, indicating that the two enzymes are encoded by different genes [1].
  • The Ntan1(-/-) mice were fertile and outwardly normal but differed from their congenic wild-type counterparts in spontaneous activity, spatial memory, and a socially conditioned exploratory phenotype that has not been previously described with other mouse strains [1].
  • When embryonic 12-day-old or newborn mice were successively exposed to magnetic fields at 100 mT for 2 h, four times per day until the postnatal seventh day, Ntan1 mRNA was significantly increased about 1.5-2-fold in the hippocampus in vivo [2].

Anatomical context of Ntan1


  1. Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Kwon, Y.T., Balogh, S.A., Davydov, I.V., Kashina, A.S., Yoon, J.K., Xie, Y., Gaur, A., Hyde, L., Denenberg, V.H., Varshavsky, A. Mol. Cell. Biol. (2000) [Pubmed]
  2. The magnetism responsive gene Ntan1 in mouse brain. Goto, Y., Taniura, H., Yamada, K., Hirai, T., Sanada, N., Nakamichi, N., Yoneda, Y. Neurochem. Int. (2006) [Pubmed]
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