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Gene Review

NTAN1  -  N-terminal asparagine amidase

Homo sapiens

Synonyms: PNAA, PNAD, Protein N-terminal Asn amidase, Protein N-terminal asparagine amidase, Protein N-terminal asparagine amidohydrolase, ...
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Disease relevance of NTAN1

  • Overexpression of Ntan1 using recombinant Ntan1 adenovirus vector resulted in a marked decrease in the MAP2 protein expression in hippocampal neurons [1].
  • With use of PNAA the following abnormalities were observed; serum carotene and folate decreased, D-xylose absorption was impaired, fat globules and muscle fibers were demonstrable in the stool, and the mean weight loss in 6 weeks was 10.2% as compared with 4.3% in patients not treated with antibiotics [2].

High impact information on NTAN1

  • The expression of mouse NtN-amidase in S. cerevisiae nta1Delta was used to verify that NtN-amidase retains its asparagine selectivity in vivo and can implement the asparagine-specific subset of the N-end rule [3].
  • The Ntan1 promoter is located approximately 500 base pairs upstream of the Ntan1 start codon [3].
  • Further dissection of mouse Ntan1, including its null phenotype analysis, should illuminate the functions of the N-end rule, most of which are still unknown [3].
  • The approximately 1.4-kilobase pair Ntan1 mRNA is expressed in all of the tested mouse tissues and cell lines and is down-regulated upon the conversion of myoblasts into myotubes [3].
  • The approximately 17-kilobase pair Ntan1 gene is located in the proximal region of mouse chromosome 16 and contains 10 exons ranging from 54 to 177 base pairs in length [3].

Associations of NTAN1 with chemical compounds

  • We report the isolation and analysis of a mouse cDNA and the corresponding gene (termed Ntan1) that encode a 310-residue amidohydrolase (termed NtN-amidase) specific for N-terminal asparagine [3].
  • Attachment of four Glu residues and two ethylene oxide spacers to the PNAA was required to confer proper hydration for extrusion and presentation for DNA hybridization [4].
  • We present a method to covalently attach peptide nucleic acid (PNA) to liposomes by conjugation of PNA peptide to charged amino acids and synthetic di-alkyl lipids ("PNA amphiphile," PNAA) followed by co-extrusion with disteroylphosphatidylcholine (DSPC) and cholesterol [4].
  • Longer DNA showed a greatly attenuated binding efficiency, likely because of electrostatic repulsion between the PNAA liposome double layer and the DNA backbone [4].
  • Methotrexate absorption decreased from a mean of 69% prior to antibiotic use to 44% on PNAA [2].

Other interactions of NTAN1

  • Our results suggest that brief magnetism leads to the induction of Ntan1 responsible for MAP2 protein degradation through ubiquitin-proteasome pathway in rat hippocampal neurons [1].

Analytical, diagnostic and therapeutic context of NTAN1


  1. Stimulation of ubiquitin-proteasome pathway through the expression of amidohydrolase for N-terminal asparagine (Ntan1) in cultured rat hippocampal neurons exposed to static magnetism. Hirai, T., Taniura, H., Goto, Y., Ogura, M., Sng, J.C., Yoneda, Y. J. Neurochem. (2006) [Pubmed]
  2. Effect of oral prophylactic broad spectrum nonabsorbable antibiotics on the gastrointestinal absorption of nutrients and methotrexate in small cell bronchogenic carcinoma patients. Cohen, M.H., Creaven, P.J., Fossieck, B.E., Johnston, A.V., Williams, C.L. Cancer (1976) [Pubmed]
  3. A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway. Grigoryev, S., Stewart, A.E., Kwon, Y.T., Arfin, S.M., Bradshaw, R.A., Jenkins, N.A., Copeland, N.G., Varshavsky, A. J. Biol. Chem. (1996) [Pubmed]
  4. Sequence-specific binding of DNA to liposomes containing di-alkyl peptide nucleic acid (PNA) amphiphiles. Marques, B.F., Schneider, J.W. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
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