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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Olfr65  -  olfactory receptor 65

Mus musculus

Synonyms: 5'[b]3, 5'beta3, GA_x6K02T2PBJ9-6634906-6633983, MOR1-1, MOR1-2, ...
 
 
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High impact information on Olfr65

  • The GABA concentration producing a half-maximal current was similar for beta 2 and beta 3 subtype-containing receptors (6 microM) but higher for beta 1 subtype-containing receptors (26 microM). alpha 5 beta 3 gamma 2L receptors were zinc and diazepam sensitive but zolpidem insensitive [1].
  • The distinct affinities of recombinant receptors for CI 218,872 suggested that the alpha 5 beta 3 gamma 2 receptor is the dominant zolpidem-insensitive GABAA receptor in the brain [2].
  • The BZ site of gamma 3-containing receptors was partially independent of the accompanying alpha and beta variants. alpha 1/5 beta 3 gamma 3 receptors were zolpidem insensitive but distinguished from alpha 5 beta 3 gamma 2 receptors by high affinity for the partial BZ receptor agonist CI 218,872 [2].
  • Hence, alpha 5 beta 3 gamma 3 recpetors are not a major fraction of the native zolpidem-insensitive receptors, even though their genes are colocalized on mouse chromosome 7 and on human chromosome 15 [2].

References

  1. Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype. Burgard, E.C., Tietz, E.I., Neelands, T.R., Macdonald, R.L. Mol. Pharmacol. (1996) [Pubmed]
  2. Impact of beta and gamma variants on ligand-binding properties of gamma-aminobutyric acid type A receptors. Lüddens, H., Seeburg, P.H., Korpi, E.R. Mol. Pharmacol. (1994) [Pubmed]
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