Disease relevance of DVL3

• In human colorectal samples, DVL-3 was expressed equally in matched normal tissues, polyps and tumours [1].
• Our results suggest that Rac1b overexpression may facilitate tumor progression by enhancing Dvl-3-mediated Wnt pathway signaling and induction of Wnt target genes specifically involved in decreasing the adhesive properties of colorectal cancer cells [2].

Psychiatry related information on DVL3

• DVL-1 and DVL-3 are members of a human dsh-like gene family, which is probably involved in human development [3].

High impact information on DVL3

• Results: We showed that Prickle-1 bound with Dvl3 and facilitated Dvl3 ubiquitination/degradation, and this was through its destruction box (D-box) motifs [4].
• DVL-1 locus maps to chromosome 1p36 and DVL-3 to chromosome 3q27 [3].
• A YAC contig was constructed that extends ca. 5.4 Mb from a region of conserved synteny with human Chr 8 at Prkdc through the region conserved with human Chr 3 at DVL3 [5].
• Here, we report the cloning of a second human homologue of Dsh (called DVL-3) by cDNA library screening [1].
• The expression of DVL-3 mRNA was detected in 30 human cell lines and 2 primary cell cultures [1].

Other interactions of DVL3

• Conclusions: Our results have elucidated a novel mechanistic relationship between Prickle-1 and Dvl3 in the Wnt/beta-catenin pathway [4].
• Blockade of Wnt-1 signaling in both experiments was confirmed by analyzing intracellular levels of Dishevelled-3 and of cytosolic beta-catenin [6].

References