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Gene Review

DVL3  -  dishevelled segment polarity protein 3

Homo sapiens

Synonyms: DSH homolog 3, Dishevelled-3, KIAA0208, Segment polarity protein dishevelled homolog DVL-3
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Disease relevance of DVL3

  • In human colorectal samples, DVL-3 was expressed equally in matched normal tissues, polyps and tumours [1].
  • Our results suggest that Rac1b overexpression may facilitate tumor progression by enhancing Dvl-3-mediated Wnt pathway signaling and induction of Wnt target genes specifically involved in decreasing the adhesive properties of colorectal cancer cells [2].

Psychiatry related information on DVL3


High impact information on DVL3


Other interactions of DVL3

  • Conclusions: Our results have elucidated a novel mechanistic relationship between Prickle-1 and Dvl3 in the Wnt/beta-catenin pathway [4].
  • Blockade of Wnt-1 signaling in both experiments was confirmed by analyzing intracellular levels of Dishevelled-3 and of cytosolic beta-catenin [6].


  1. cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. Bui, T.D., Beier, D.R., Jonssen, M., Smith, K., Dorrington, S.M., Kaklamanis, L., Kearney, L., Regan, R., Sussman, D.J., Harris, A.L. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  2. Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. Esufali, S., Charames, G.S., Pethe, V.V., Buongiorno, P., Bapat, B. Cancer Res. (2007) [Pubmed]
  3. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Pizzuti, A., Amati, F., Calabrese, G., Mari, A., Colosimo, A., Silani, V., Giardino, L., Ratti, A., Penso, D., Calzà, L., Palka, G., Scarlato, G., Novelli, G., Dallapiccola, B. Hum. Mol. Genet. (1996) [Pubmed]
  4. Prickle-1 Negatively Regulates Wnt/beta-Catenin Pathway by Promoting Dishevelled Ubiquitination/Degradation in Liver Cancer. Chan, D.W., Chan, C.Y., Yam, J.W., Ching, Y.P., Ng, I.O. Gastroenterology (2006) [Pubmed]
  5. Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2. Lund, J., Roe, B., Chen, F., Budarf, M., Galili, N., Riblet, R., Miller, R.D., Emanuel, B.S., Reeves, R.H. Mamm. Genome (1999) [Pubmed]
  6. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells. Mikami, I., You, L., He, B., Xu, Z., Batra, S., Lee, A.Y., Mazieres, J., Reguart, N., Uematsu, K., Koizumi, K., Jablons, D.M. BMC Cancer (2005) [Pubmed]
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