Disease relevance of Pa2g4

• Proliferation-associated Ki-67 protein is a target for autoantibodies in the human autoimmune disease systemic lupus erythematosus [1].

High impact information on Pa2g4

• Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins [2].
• We propose that the authentic protein encoded by this cDNA be called cytoplasmic activation/proliferation-associated protein-1 (caprin-1), and show that it is the prototype of a novel family of proteins characterized by two novel protein domains, termed homology regions-1 and -2 (HR-1, HR-2) [2].
• Endoglycosidase F treatment revealed the peptide cores of the antigen to be approximately 32 to 38kDa under reducing conditions and they possess at least three glycosylation side-chains [3].
• Proliferation-associated oxygen consumption and morphology of tumor cells in monolayer and spheroid culture [4].
• Immunoblotting indicated that the amounts of protein of about 38kDa were higher in the brain and testis than in other tissues [5].

Biological context of Pa2g4

• Most parts of the 44-kDa protein cDNA and the deduced amino acid sequence were found to be identical to those of the protein p38-2G4, recently reported as a cell cycle-specifically modulated nuclear protein of 38kDa [6].
• We have identified a novel human gene with strong homology to the mouse Pa2g4 cell cycle gene [7].

Anatomical context of Pa2g4

• Proliferation-associated increase in sensitivity of mammary epithelial cells to inositol-1,4,5-trisphosphate [8].

Analytical, diagnostic and therapeutic context of Pa2g4

• Endogenous Ebp1 was recruited to the E2F1 promoter in vivo as demonstrated by chromatin immunoprecipitation assays [9].

References