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Gene Review:

spo-11 - Protein SPO-11

Caenorhabditis elegans

Rinaldo, C. et al., Bowring, F.J. et al., Dernburg, A.F. et al.

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High impact information on spo-11

However, homologous synapsis is independent of recombination in the nematode, since it occurs normally in a C. elegans spo-11 null mutant [1].
If double-strand breaks are prevented by spo-11 mutation, rad-51 RNAi does not affect chromosome appearance [2].
Chromosome pairing and meiotic recombination in Neurospora crassa spo11 mutants [3].
Crossing over in a spo11 mutant is reduced in two regions of the Neurospora genome as expected, but is unaffected in a third [3].
Although it was previously suggested that Neurospora may not require DSBs for synapsis, we report here that mutation of Neurospora spo11 disrupts meiosis, abolishing synapsis of homologous chromosomes during pachynema and resulting in ascospores that are frequently aneuploid and rarely viable [3].

References

Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis. Dernburg, A.F., McDonald, K., Moulder, G., Barstead, R., Dresser, M., Villeneuve, A.M. Cell (1998) [Pubmed]
Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development. Rinaldo, C., Bazzicalupo, P., Ederle, S., Hilliard, M., La Volpe, A. Genetics (2002) [Pubmed]
Chromosome pairing and meiotic recombination in Neurospora crassa spo11 mutants. Bowring, F.J., Yeadon, P.J., Stainer, R.G., Catcheside, D.E. Curr. Genet. (2006) [Pubmed]

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