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Gene Review

rad-51  -  Protein RAD-51

Caenorhabditis elegans

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Disease relevance of rad-51


High impact information on rad-51

  • Unlike rad-51 mutants, Cebrc-2 mutants also accumulate RPA-1 at DSBs, and abnormal chromosome aggregates that arise during the meiotic prophase can be rescued by blocking the NHEJ pathway [2].
  • CeBRC-2 also forms foci in response to DNA damage and can do so independently of rad-51 [2].
  • Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line [3].
  • These results reveal RAD-51-dependent and -independent functions of CeBRC-2 that provide an explanation for the difference in DNA repair defects observed in Cebrc-2 and rad-51 mutants, and define mechanistic roles for CeBRC-2 in HR and in the SSA pathway for DSB repair [4].
  • Silencing of the rad-51 gene also causes a reduction in fecundity, which is suppressed by mutation in the DNA damage checkpoint gene rad-5, but not in the cell death effector gene ced-3 [5].

Biological context of rad-51


Other interactions of rad-51


  1. Efficient repair of DNA damage induced by heavy ion particles in meiotic prophase I nuclei of Caenorhabditis elegans. Takanami, T., Zhang, Y., Aoki, H., Abe, T., Yoshida, S., Takahashi, H., Horiuchi, S., Higashitani, A. J. Radiat. Res. (2003) [Pubmed]
  2. RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Martin, J.S., Winkelmann, N., Petalcorin, M.I., McIlwraith, M.J., Boulton, S.J. Mol. Cell. Biol. (2005) [Pubmed]
  3. Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line. Wicky, C., Alpi, A., Passannante, M., Rose, A., Gartner, A., Müller, F. Mol. Cell. Biol. (2004) [Pubmed]
  4. CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. Petalcorin, M.I., Sandall, J., Wigley, D.B., Boulton, S.J. J. Mol. Biol. (2006) [Pubmed]
  5. Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development. Rinaldo, C., Bazzicalupo, P., Ederle, S., Hilliard, M., La Volpe, A. Genetics (2002) [Pubmed]
  6. Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans. Alpi, A., Pasierbek, P., Gartner, A., Loidl, J. Chromosoma (2003) [Pubmed]
  7. Caenorhabditis elegans Ce-rdh-1/rad-51 functions after double-strand break formation of meiotic recombination. Takanami, T., Mori, A., Takahashi, H., Horiuchi, S., Higashitani, A. Chromosome Res. (2003) [Pubmed]
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