Disease relevance of Psmc3

• These results indicate that the Mab 1.48-reactive epitope of Tbp2 is surface exposed when it is expressed without Tbp1 in E. coli while the inaccessibility of this epitope of Tbp2 in A. pp could be due to shading by the association between Tbp2 and Tbp1 [1].

High impact information on Psmc3

• The Psmc3 gene mapped to mouse chromosome 2, whereas Psmc4 mapped to chromosome 7 [2].
• The Psmc3 gene was composed of 12 coding exons, whereas the Psmc4 gene had 11 exons [2].
• These findings indicate that Psmc3 and Psmc4 have similar and essential roles in early embryogenesis and further that both ATPases have noncompensatory functions in vivo [2].
• Exons encoding the leucine zipper domain and CAD were identical in number between the Psmc3 and Psmc4 genes [2].
• Indications of an IMT mechanism originated from the finding that two proteins associated with the manchette (Sak57/K5 and TBP-1, the latter a component of the 26S proteasome) repositioned to the centrosome and sperm tail once the manchette disassembled [3].

Anatomical context of Psmc3

• Both Psmc3- and Psmc4-deficient mice died before implantation, displaying defective blastocyst development [2].

Analytical, diagnostic and therapeutic context of Psmc3

• Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting [2].

References