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PSMC3  -  proteasome (prosome, macropain) 26S...

Homo sapiens

Synonyms: 26S protease regulatory subunit 6A, 26S proteasome AAA-ATPase subunit RPT5, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, TBP-1, ...
 
 
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Disease relevance of PSMC3

  • The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes [1].
  • Similarities in size between hemin-binding protein 1 (HmBP1) and transferrin-binding protein 1 (TBP1) of Neisseria meningitidis suggest that these proteins are functionally homologous [2].
  • These results indicate that Desulfovibrio sp. strain TBP-1 is capable of growth via halorespiration [3].
  • Biochemical and immunological characterization of rice homologues of the human immunodeficiency virus-1 Tat binding protein and subunit 4 of human 26S proteasome subunits [4].
  • We found that phages displaying TBP-1 bound to Ti, Si, and Ag surfaces but not to Au, Cr, Pt, Sn, Zn, Cu, or Fe [5].
 

High impact information on PSMC3

 

Chemical compound and disease context of PSMC3

  • Average growth yields (milligrams of protein per millimole of electrons utilized) for Desulfovibrio sp. strain TBP-1 grown with 2,4,6-bromophenol, 4-bromophenol, or sulfate are 0.62, 0.71, and 1.07, respectively [3].
 

Biological context of PSMC3

 

Anatomical context of PSMC3

 

Associations of PSMC3 with chemical compounds

 

Other interactions of PSMC3

 

Analytical, diagnostic and therapeutic context of PSMC3

  • Molecular cloning and developmental regulation of Dictyostelium discoideum homologues of the human and yeast HIV1 Tat-binding protein [16].
  • Human convalescent-phase sera obtained from five patients infected with meningococci of different serogroups and serotypes contained fully cross-reactive antibodies to TBP2 but no anti-TBP1 antibodies, when examined on Western blots [17].

References

  1. The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. Ohana, B., Moore, P.A., Ruben, S.M., Southgate, C.D., Green, M.R., Rosen, C.A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Acquisition of heme iron by Neisseria meningitidis does not involve meningococcal transferrin-binding proteins. Martel, N., Lee, B.C. Infect. Immun. (1994) [Pubmed]
  3. Isolation from estuarine sediments of a Desulfovibrio strain which can grow on lactate coupled to the reductive dehalogenation of 2,4, 6-tribromophenol. Boyle, A.W., Phelps, C.D., Young, L.Y. Appl. Environ. Microbiol. (1999) [Pubmed]
  4. Biochemical and immunological characterization of rice homologues of the human immunodeficiency virus-1 Tat binding protein and subunit 4 of human 26S proteasome subunits. Suzuka, I., Yanagawa, Y., Yamazaki, K., Ueda, T., Nakagawa, H., Hashimoto, J. Plant Mol. Biol. (1998) [Pubmed]
  5. Specificity and biomineralization activities of Ti-binding peptide-1 (TBP-1). Sano, K., Sasaki, H., Shiba, K. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  6. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Corn, P.G., McDonald, E.R., Herman, J.G., El-Deiry, W.S. Nat. Genet. (2003) [Pubmed]
  7. A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator. Nelbock, P., Dillon, P.J., Perkins, A., Rosen, C.A. Science (1990) [Pubmed]
  8. Induction of the Tat-binding protein 1 gene accompanies the disabling of oncogenic erbB receptor tyrosine kinases. Park, B.W., O'Rourke, D.M., Wang, Q., Davis, J.G., Post, A., Qian, X., Greene, M.I. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1). Hoyle, J., Tan, K.H., Fisher, E.M. Hum. Genet. (1997) [Pubmed]
  10. Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1. Pollice, A., Nasti, V., Ronca, R., Vivo, M., Lo Iacono, M., Calogero, R., Calabrò, V., La Mantia, G. J. Biol. Chem. (2004) [Pubmed]
  11. Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene. Ijichi, H., Tanaka, T., Nakamura, T., Yagi, H., Hakuba, A., Sato, M. Gene (2000) [Pubmed]
  12. Cloning and heterogeneous in vivo expression of Tat binding protein-1 (TBP-1) in the mouse. Nakamura, T., Tanaka, T., Takagi, H., Sato, M. Biochim. Biophys. Acta (1998) [Pubmed]
  13. Human immunodeficiency virus type 1 Tat binding protein-1 is a transcriptional coactivator specific for TR. Ishizuka, T., Satoh, T., Monden, T., Shibusawa, N., Hashida, T., Yamada, M., Mori, M. Mol. Endocrinol. (2001) [Pubmed]
  14. Identification and characterization of genes encoding the human transferrin-binding proteins from Haemophilus influenzae. Gray-Owen, S.D., Loosmore, S., Schryvers, A.B. Infect. Immun. (1995) [Pubmed]
  15. Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms. Hastings, R., Walker, G., Eyheralde, I., Dawson, S., Billett, M., Mayer, R.J. Mol. Biol. Rep. (1999) [Pubmed]
  16. Molecular cloning and developmental regulation of Dictyostelium discoideum homologues of the human and yeast HIV1 Tat-binding protein. Shaw, D.R., Ennis, H.L. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  17. Immune responses in humans and animals to meningococcal transferrin-binding proteins: implications for vaccine design. Ala'Aldeen, D.A., Stevenson, P., Griffiths, E., Gorringe, A.R., Irons, L.I., Robinson, A., Hyde, S., Borriello, S.P. Infect. Immun. (1994) [Pubmed]
 
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