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Gene Review:

Rad50 - RAD50 homolog (S. cerevisiae)

Mus musculus

Synonyms: DNA repair protein RAD50, Mrell, Rad50l, mRad50

Luo, G. et al., Lee, G.R. et al., Luo, Q. et al., Bender, C.F. et al., Yoon, B.I. et al.

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High impact information on Rad50

Mre11, Rad50, and Nbs1 function in a protein complex that is central to the metabolism of chromosome breaks [1].
Deletion of RHS7 did not affect the expression of a linked Rad50 gene, but it did reduce long-range intrachromosomal interactions between the locus control region and promoters of the T(H)2 cytokine genes [2].
We established mRad50 mutant mice to examine the role of the mammalian Mre11/Rad50 protein complex in the DNA damage response [3].
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation [3].
(d) DNA repair genes such as Rad50 and Rad51 are markedly downregulated in p53-KO mice [4].

Biological context of Rad50

Furthermore, the data obtained also showed that EMFs could activate the DNA damage-repair mechanism by recruiting repair factor Rad50 to the damaged DNA sites to repair the corresponding DNA damage [5].

References

Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Bender, C.F., Sikes, M.L., Sullivan, R., Huye, L.E., Le Beau, M.M., Roth, D.B., Mirzoeva, O.K., Oltz, E.M., Petrini, J.H. Genes Dev. (2002) [Pubmed]
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Lee, G.R., Spilianakis, C.G., Flavell, R.A. Nat. Immunol. (2005) [Pubmed]
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Luo, G., Yao, M.S., Bender, C.F., Mills, M., Bladl, A.R., Bradley, A., Petrini, J.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue. Yoon, B.I., Li, G.X., Kitada, K., Kawasaki, Y., Igarashi, K., Kodama, Y., Inoue, T., Kobayashi, K., Kanno, J., Kim, D.Y., Inoue, T., Hirabayashi, Y. Environ. Health Perspect. (2003) [Pubmed]
50-Hertz Electromagnetic Fields Induce gammaH2AX Foci Formation in Mouse Preimplantation Embryos In Vitro. Luo, Q., Yang, J., Zeng, Q.L., Zhu, X.M., Qian, Y.L., Huang, H.F. Biol. Reprod. (2006) [Pubmed]

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AgaP_AGAP003676	Anopheles gambiae str. PEST
RAD50	Arabidopsis thaliana
RAD50	Bos taurus
RAD50	Canis lupus familiaris
rad50	Danio rerio
rad50	Drosophila melanogaster
RAD50	Gallus gallus
RAD50	Homo sapiens
RAD50	Macaca mulatta
MGG_11387	Magnaporthe oryzae 70-15
NCU00901	Neurospora crassa OR74A
Os02g0497500	Oryza sativa Japonica Group
RAD50	Pan troglodytes
Rad50	Rattus norvegicus
rad50	Xenopus (Silurana) tropicalis

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