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Gene Review

Rad50  -  RAD50 homolog (S. cerevisiae)

Mus musculus

Synonyms: DNA repair protein RAD50, Mrell, Rad50l, mRad50
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High impact information on Rad50


Biological context of Rad50

  • Furthermore, the data obtained also showed that EMFs could activate the DNA damage-repair mechanism by recruiting repair factor Rad50 to the damaged DNA sites to repair the corresponding DNA damage [5].


  1. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Bender, C.F., Sikes, M.L., Sullivan, R., Huye, L.E., Le Beau, M.M., Roth, D.B., Mirzoeva, O.K., Oltz, E.M., Petrini, J.H. Genes Dev. (2002) [Pubmed]
  2. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Lee, G.R., Spilianakis, C.G., Flavell, R.A. Nat. Immunol. (2005) [Pubmed]
  3. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Luo, G., Yao, M.S., Bender, C.F., Mills, M., Bladl, A.R., Bradley, A., Petrini, J.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Mechanisms of benzene-induced hematotoxicity and leukemogenicity: cDNA microarray analyses using mouse bone marrow tissue. Yoon, B.I., Li, G.X., Kitada, K., Kawasaki, Y., Igarashi, K., Kodama, Y., Inoue, T., Kobayashi, K., Kanno, J., Kim, D.Y., Inoue, T., Hirabayashi, Y. Environ. Health Perspect. (2003) [Pubmed]
  5. 50-Hertz Electromagnetic Fields Induce gammaH2AX Foci Formation in Mouse Preimplantation Embryos In Vitro. Luo, Q., Yang, J., Zeng, Q.L., Zhu, X.M., Qian, Y.L., Huang, H.F. Biol. Reprod. (2006) [Pubmed]
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