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Gene Review

RAD50  -  DNA repair protein RAD50

Arabidopsis thaliana

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Disease relevance of RAD50


High impact information on RAD50

  • RAD50 function is essential for telomere maintenance in Arabidopsis [2].
  • We have identified and characterized an Arabidopsis thaliana rad50 mutant plant containing a T-DNA insertion in the AtRAD50 gene and showing both meiotic and DNA repair defects [2].
  • The Rad50/Mre11/Xrs2 protein complex acts at DNA ends and is implicated in both homologous and non-homologous recombination [3].
  • We have isolated a rad50 mutant of the plant Arabidopsis thaliana and show here that it has a somatic hyper-recombination phenotype in planta [3].
  • The Rad50 protein is involved in the cellular response to DNA-double strand breaks (DSBs), including the detection of damage, activation of cell-cycle checkpoints, and DSB repair via recombination [1].

Biological context of RAD50


Other interactions of RAD50


  1. Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity. Gallego, M.E., Jeanneau, M., Granier, F., Bouchez, D., Bechtold, N., White, C.I. Plant J. (2001) [Pubmed]
  2. RAD50 function is essential for telomere maintenance in Arabidopsis. Gallego, M.E., White, C.I. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Homologous recombination in planta is stimulated in the absence of Rad50. Gherbi, H., Gallego, M.E., Jalut, N., Lucht, J.M., Hohn, B., White, C.I. EMBO Rep. (2001) [Pubmed]
  4. Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination. Bleuyard, J.Y., Gallego, M.E., White, C.I. Chromosoma (2004) [Pubmed]
  5. The plant Rad50-Mre11 protein complex. Daoudal-Cotterell, S., Gallego, M.E., White, C.I. FEBS Lett. (2002) [Pubmed]
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