Gene Review:
RAD50 - RAD50 homolog (S. cerevisiae)
Homo sapiens
Synonyms:
DNA repair protein RAD50, NBSLD, RAD50-2, RAD502, hRAD50, ...
- DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. Pichierri, P., Averbeck, D., Rosselli, F. Hum. Mol. Genet. (2002)
- RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. Heikkinen, K., Rapakko, K., Karppinen, S.M., Erkko, H., Knuutila, S., Lundán, T., Mannermaa, A., Børresen-Dale, A.L., Borg, A., Barkardottir, R.B., Petrini, J., Winqvist, R. Carcinogenesis (2006)
- Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. Heikkinen, K., Karppinen, S.M., Soini, Y., Mäkinen, M., Winqvist, R. J. Med. Genet. (2003)
- Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Stracker, T.H., Carson, C.T., Weitzman, M.D. Nature (2002)
- Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Zhao, S., Weng, Y.C., Yuan, S.S., Lin, Y.T., Hsu, H.C., Lin, S.C., Gerbino, E., Song, M.H., Zdzienicka, M.Z., Gatti, R.A., Shay, J.W., Ziv, Y., Shiloh, Y., Lee, E.Y. Nature (2000)
- Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Varley, H., Pickett, H.A., Foxon, J.L., Reddel, R.R., Royle, N.J. Nat. Genet. (2002)
- New glimpses of an old machine. Paull, T.T. Cell (2001)
- Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Zhu, X.D., Küster, B., Mann, M., Petrini, J.H., de Lange, T. Nat. Genet. (2000)
- The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Stewart, G.S., Maser, R.S., Stankovic, T., Bressan, D.A., Kaplan, M.I., Jaspers, N.G., Raams, A., Byrd, P.J., Petrini, J.H., Taylor, A.M. Cell (1999)
- MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Larson, E.D., Cummings, W.J., Bednarski, D.W., Maizels, N. Mol. Cell (2005)
- Overexpressed human RAD50 exhibits cell death in a p21(WAF1/CIP1)-dependent manner: its potential utility in local gene therapy of tumor. Shin, B.A., Ahn, K.Y., Kook, H., Koh, J.T., Kang, I.C., Lee, H.C., Kim, K.K. Cell Growth Differ. (2001)
- Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Borgmann, K., Röper, B., El-Awady, R., Brackrock, S., Bigalke, M., Dörk, T., Alberti, W., Dikomey, E., Dahm-Daphi, J. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2002)
- Nitric oxide-dependent cytoskeletal changes and inhibition of endothelial cell migration contribute to the suppression of angiogenesis by RAD50 gene transfer. Kook, H., Ahn, K.Y., Lee, S.E., Na, H.S., Kim, K.K. FEBS Lett. (2003)
- Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes. Monticelli, S., Ansel, K.M., Lee, D.U., Rao, A. Novartis Found. Symp. (2005)
- hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Maser, R.S., Monsen, K.J., Nelms, B.E., Petrini, J.H. Mol. Cell. Biol. (1997)
- Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Dolganov, G.M., Maser, R.S., Novikov, A., Tosto, L., Chong, S., Bressan, D.A., Petrini, J.H. Mol. Cell. Biol. (1996)
- Active role for nibrin in the kinetics of atm activation. Cerosaletti, K., Wright, J., Concannon, P. Mol. Cell. Biol. (2006)
- Molecular cloning and characterization of splice variants of human RAD50 gene. Kim, K.K., Shin, B.A., Seo, K.H., Kim, P.N., Koh, J.T., Kim, J.H., Park, B.R. Gene (1999)
- Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Munshi, A., Tanaka, T., Hobbs, M.L., Tucker, S.L., Richon, V.M., Meyn, R.E. Mol. Cancer Ther. (2006)
- The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Hopfner, K.P., Craig, L., Moncalian, G., Zinkel, R.A., Usui, T., Owen, B.A., Karcher, A., Henderson, B., Bodmer, J.L., McMurray, C.T., Carney, J.P., Petrini, J.H., Tainer, J.A. Nature (2002)
- Mutations in the RAD54 recombination gene in primary cancers. Matsuda, M., Miyagawa, K., Takahashi, M., Fukuda, T., Kataoka, T., Asahara, T., Inui, H., Watatani, M., Yasutomi, M., Kamada, N., Dohi, K., Kamiya, K. Oncogene (1999)
- MRE11/RAD50/NBS1: complex activities. Assenmacher, N., Hopfner, K.P. Chromosoma (2004)
- Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Zhong, Q., Chen, C.F., Li, S., Chen, Y., Wang, C.C., Xiao, J., Chen, P.L., Sharp, Z.D., Lee, W.H. Science (1999)
- Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A. Nazarov, I.B., Smirnova, A.N., Krutilina, R.I., Svetlova, M.P., Solovjeva, L.V., Nikiforov, A.A., Oei, S.L., Zalenskaya, I.A., Yau, P.M., Bradbury, E.M., Tomilin, N.V. Radiat. Res. (2003)
- Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair. Jakob, B., Scholz, M., Taucher-Scholz, G. Int. J. Radiat. Biol. (2002)
- Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair. Xu, M., Myerson, R.J., Straube, W.L., Moros, E.G., Lagroye, I., Wang, L.L., Lee, J.T., Roti Roti, J.L. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (2002)
- Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Furuta, S., Jiang, X., Gu, B., Cheng, E., Chen, P.L., Lee, W.H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Desai-Mehta, A., Cerosaletti, K.M., Concannon, P. Mol. Cell. Biol. (2001)
- Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. Cerosaletti, K., Concannon, P. J. Biol. Chem. (2004)
- Telomere maintenance without telomerase. Lundblad, V. Oncogene (2002)
- Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex. Jiang, W.Q., Zhong, Z.H., Henson, J.D., Neumann, A.A., Chang, A.C., Reddel, R.R. Mol. Cell. Biol. (2005)
- Effect of human RAD50 gene therapy on glaucoma filtering surgery in rabbit eye. Yoon, K.C., Yang, K.J., Seo, J.S., Lee, S.E., Heo, T., Chun, B.J., Jung, S., Kim, K.K., Ahn, K.Y. Curr. Eye Res. (2004)
- A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks. Williams, R.S., Tainer, J.A. Mol. Cell (2005)