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Gene Review

EFNA3  -  ephrin-A3

Homo sapiens

Synonyms: EFL-2, EFL2, EHK1 ligand, EHK1-L, EPH-related receptor tyrosine kinase ligand 3, ...
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Disease relevance of EFNA3


High impact information on EFNA3

  • As such, EphA2/ephrin-A3 interactions may play a role in the localization and network of Langerhans cells in the epithelium and in the regulation of their trafficking [2].
  • Identification and characterization of splice variants of ephrin-A3 and ephrin-A5 [3].
  • The comparison of expression profiles revealed that normal prostate and primary prostate tumor cell lines differ in the expression of EphA3, EphB3, and ephrin A3 that are over-expressed in normal prostate [4].
  • Conclusion: These results lead us to the hypothesis that both BMP2 and ephrin A3 function as hair growth promoting factors in the hair cycle [5].
  • Both BMP2 and ephrin A3 raised the proliferation rate of the outer root sheath cells (ORSCs) and induced gene expression in acidic hair keratin 3-II [5].

Biological context of EFNA3

  • Although several patterns of early gene expression are stable (e.g., EphA3, EphA4, and EphA6), others change as development proceeds (e.g., EphA5, EphA7, ephrin-A2, ephrin-A3, and ephrin-A5), perhaps responding to extrinsic cues [6].

Anatomical context of EFNA3

  • These observations suggest that ephrin-A3 plays an important role in the layer-specific termination of the perforant pathway and that this ligand may interact with the EphA5 receptor to restrict entorhinal axon terminals in the outer molecular layer of the dentate gyrus [7].
  • Thus, at E95, after connections between the cortical plate and thalamus have formed, receptor subtypes EphA3, EphA5, EphA6, and EphA7 and the ligand ephrin-A5 are expressed in posterior regions, whereas EphA4 and ephrin-A2 and ephrin-A3 are either uniformly distributed or anteriorly biased [6].


  1. Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. Hafner, C., Schmitz, G., Meyer, S., Bataille, F., Hau, P., Langmann, T., Dietmaier, W., Landthaler, M., Vogt, T. Clin. Chem. (2004) [Pubmed]
  2. Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin. de Saint-Vis, B., Bouchet, C., Gautier, G., Valladeau, J., Caux, C., Garrone, P. Blood (2003) [Pubmed]
  3. Identification and characterization of splice variants of ephrin-A3 and ephrin-A5. Lai, K.O., Ip, F.C., Ip, N.Y. FEBS Lett. (1999) [Pubmed]
  4. Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines. Fox, B.P., Tabone, C.J., Kandpal, R.P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis. Midorikawa, T., Chikazawa, T., Yoshino, T., Takada, K., Arase, S. J. Dermatol. Sci. (2004) [Pubmed]
  6. Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex. Donoghue, M.J., Rakic, P. J. Neurosci. (1999) [Pubmed]
  7. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. Stein, E., Savaskan, N.E., Ninnemann, O., Nitsch, R., Zhou, R., Skutella, T. J. Neurosci. (1999) [Pubmed]
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