The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Efna3  -  ephrin A3

Mus musculus

Synonyms: AW494418, EFL-2, EHK1 ligand, EHK1-L, EPH-related receptor tyrosine kinase ligand 3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Efna3

  • Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted [1].
  • Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling [2].
  • Here we describe a repulsive interaction that regulates postsynaptic morphology through the EphA4 receptor tyrosine kinase and its ligand ephrin-A3 [2].
  • In the olfactory system, high levels of Lerk3 were detected in the sensory neurons [3].
  • In addition, Southern blot analysis of DNA from interspecific backcross mice indicated that the mouse homologues Epl1, Epl3, and Epl4 map to a homologous region on mouse chromosome 3 [4].

Anatomical context of Efna3


Associations of Efna3 with chemical compounds

  • Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development [6].

Other interactions of Efna3

  • In the lateral wall, EphA4, ephrin-A3 and ephrin-B2 were strongly expressed, while ephrin-A3 was particularly strongly expressed in utricular and saccular sensory epithelia [5].


  1. Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping. Pfeiffenberger, C., Cutforth, T., Woods, G., Yamada, J., Rentería, R.C., Copenhagen, D.R., Flanagan, J.G., Feldheim, D.A. Nat. Neurosci. (2005) [Pubmed]
  2. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Murai, K.K., Nguyen, L.N., Irie, F., Yamaguchi, Y., Pasquale, E.B. Nat. Neurosci. (2003) [Pubmed]
  3. Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk: potential roles in neuron-target interaction. Zhang, J.H., Cerretti, D.P., Yu, T., Flanagan, J.G., Zhou, R. J. Neurosci. (1996) [Pubmed]
  4. The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Cerretti, D.P., Lyman, S.D., Kozlosky, C.J., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Valentine, V., Kirstein, M.N., Shapiro, D.N., Morris, S.W. Genomics (1996) [Pubmed]
  5. Expression of Ephs and ephrins in developing mouse inner ear. Pickles, J.O. Hear. Res. (2003) [Pubmed]
  6. Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development. Duffy, S.L., Steiner, K.A., Tam, P.P., Boyd, A.W. Gene Expr. Patterns (2006) [Pubmed]
WikiGenes - Universities