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MeSH Review

Werner Syndrome

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Disease relevance of Werner Syndrome


High impact information on Werner Syndrome


Chemical compound and disease context of Werner Syndrome


Biological context of Werner Syndrome


Anatomical context of Werner Syndrome


Gene context of Werner Syndrome


  1. Extrachromosomal rDNA circles--a cause of aging in yeast. Sinclair, D.A., Guarente, L. Cell (1997) [Pubmed]
  2. Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Yamagata, K., Kato, J., Shimamoto, A., Goto, M., Furuichi, Y., Ikeda, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors. Rasio, D., Murakumo, Y., Robbins, D., Roth, T., Silver, A., Negrini, M., Schmidt, C., Burczak, J., Fishel, R., Croce, C.M. Cancer Res. (1997) [Pubmed]
  4. Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae. Bennett, R.J., Sharp, J.A., Wang, J.C. J. Biol. Chem. (1998) [Pubmed]
  5. Enhanced intra-abdominal visceral fat accumulation in patients with Werner's syndrome. Mori, S., Murano, S., Yokote, K., Takemoto, M., Asaumi, S., Take, A., Saito, Y. Int. J. Obes. Relat. Metab. Disord. (2001) [Pubmed]
  6. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Chang, S., Multani, A.S., Cabrera, N.G., Naylor, M.L., Laud, P., Lombard, D., Pathak, S., Guarente, L., DePinho, R.A. Nat. Genet. (2004) [Pubmed]
  7. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Wyllie, F.S., Jones, C.J., Skinner, J.W., Haughton, M.F., Wallis, C., Wynford-Thomas, D., Faragher, R.G., Kipling, D. Nat. Genet. (2000) [Pubmed]
  8. Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase. Cogoni, C., Macino, G. Science (1999) [Pubmed]
  9. Diminished response of Werner's syndrome fibroblasts to growth factors PDGF and FGF. Bauer, E.A., Silverman, N., Busiek, D.F., Kronberger, A., Deuel, T.F. Science (1986) [Pubmed]
  10. Congestive cardiomyopathy in Werner's syndrome. Tri, T.B., Combs, D.T. Lancet (1978) [Pubmed]
  11. Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization. Shiratori, M., Sakamoto, S., Suzuki, N., Tokutake, Y., Kawabe, Y., Enomoto, T., Sugimoto, M., Goto, M., Matsumoto, T., Furuichi, Y. J. Cell Biol. (1999) [Pubmed]
  12. Troglitazone ameliorates insulin resistance in patients with Werner's syndrome. Izumino, K., Sakamaki, H., Ishibashi, M., Takino, H., Yamasaki, H., Yamaguchi, Y., Chikuba, N., Matsumoto, K., Akazawa, S., Tokuyama, K., Nagataki, S. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  13. Turnover of sulfated glycosaminoglycans in fibroblasts derived from patients with Werner's syndrome. Cowles, E.A., Brauker, J.H., Anderson, R.L. Exp. Cell Res. (1987) [Pubmed]
  14. Lack of effect of caffeine post-treatment on X-ray-induced chromosomal aberrations in Werner's syndrome lymphoblastoid cell lines: a preliminary report. Franchitto, A., Proietti De Santis, L., Pichierri, P., Mosesso, P., Palitti, F. Int. J. Radiat. Biol. (1999) [Pubmed]
  15. Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis. Li, W., Wang, J.C. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  16. Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53. Yamabe, Y., Shimamoto, A., Goto, M., Yokota, J., Sugawara, M., Furuichi, Y. Mol. Cell. Biol. (1998) [Pubmed]
  17. RecQ-like helicases: the DNA replication checkpoint connection. Frei, C., Gasser, S.M. J. Cell. Sci. (2000) [Pubmed]
  18. The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer. Mutations in brief no. 136. Online. Vidal, V., Bay, J.O., Champomier, F., Grancho, M., Beauville, L., Glowaczower, C., Lemery, D., Ferrara, M., Bignon, Y.J. Hum. Mutat. (1998) [Pubmed]
  19. Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population. Matsumoto, T., Imamura, O., Yamabe, Y., Kuromitsu, J., Tokutake, Y., Shimamoto, A., Suzuki, N., Satoh, M., Kitao, S., Ichikawa, K., Kataoka, H., Sugawara, K., Thomas, W., Mason, B., Tsuchihashi, Z., Drayna, D., Sugawara, M., Sugimoto, M., Furuichi, Y., Goto, M. Hum. Genet. (1997) [Pubmed]
  20. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Poot, M., Hoehn, H., Rünger, T.M., Martin, G.M. Exp. Cell Res. (1992) [Pubmed]
  21. Normal thermostability of hypoxanthine guanine phosphoribosyltransferase in erythrocytes from Werner's syndrome patients. Takeuchi, F., Goto, M., Miyamoto, T. Gerontology. (1986) [Pubmed]
  22. Metabolism of acetylated low density lipoproteins by monocyte-derived macrophages from patients with Werner's syndrome. Mori, S., Morisaki, N., Saito, Y., Yoshida, S. Arteriosclerosis (1989) [Pubmed]
  23. Binding and tyrosine kinase activities of the insulin receptor on Epstein-Barr virus transformed lymphocytes from patients with Werner's syndrome. Kakehi, T., Kuzuya, H., Yoshimasa, Y., Yamada, K., Okamoto, M., Nishimura, H., Imura, H. Journal of gerontology. (1988) [Pubmed]
  24. Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint. Chakraverty, R.K., Kearsey, J.M., Oakley, T.J., Grenon, M., de La Torre Ruiz, M.A., Lowndes, N.F., Hickson, I.D. Mol. Cell. Biol. (2001) [Pubmed]
  25. Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene. Onoda, F., Seki, M., Miyajima, A., Enomoto, T. Mutat. Res. (2000) [Pubmed]
  26. Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA. Rodríguez-López, A.M., Jackson, D.A., Nehlin, J.O., Iborra, F., Warren, A.V., Cox, L.S. Mech. Ageing Dev. (2003) [Pubmed]
  27. Close linkage of the gene for Werner's syndrome to ANK1 and D8S87 on the short arm of chromosome 8. Nakura, J., Miki, T., Nagano, K., Kihara, K., Ye, L., Kamino, K., Fujiwara, Y., Yoshida, S., Murano, S., Fukuchi, K. Gerontology. (1993) [Pubmed]
  28. LMNA mutations in atypical Werner's syndrome. Chen, L., Lee, L., Kudlow, B.A., Dos Santos, H.G., Sletvold, O., Shafeghati, Y., Botha, E.G., Garg, A., Hanson, N.B., Martin, G.M., Mian, I.S., Kennedy, B.K., Oshima, J. Lancet (2003) [Pubmed]
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