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MeSH Review

Aging, Premature

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Disease relevance of Aging, Premature


Psychiatry related information on Aging, Premature


High impact information on Aging, Premature


Chemical compound and disease context of Aging, Premature

  • We discovered this polymorphism when we cloned the mitochondrial manganese-containing superoxide dismutase from cell lines of normal individuals and patients with genetic diseases of premature aging and compared their sequences to each other and to those previously reported [12].
  • Brain cell alterations suggesting premature aging induced by dietary deficiency of vitamin B6 and/or copper [13].
  • Experiments investigating the effects of endogenous excitatory amino acid antagonists and stimulants of melatonin biosynthesis such as magnesium may finally lead to novel therapeutic approaches for the prevention of degeneration and dysdifferentiation associated with diseases related to premature aging [14].
  • It was hypothesized that such glucose-induced premature aging in animals with a genetically restricted potential for beta-cell proliferation could contribute to the precipitation of overt diabetes [15].
  • Finally, estradiol has been shown to produce premature aging of the hypothalamic arcuate nucleus, which secretes gonadotropin-releasing hormone [16].

Biological context of Aging, Premature


Anatomical context of Aging, Premature


Gene context of Aging, Premature

  • Several other replication mutations, such as rad27 Delta, encoding the FEN-1 nuclease involved in several aspects of genomic stability, also show premature aging [25].
  • Late-generation sgs1 and srs2 cells senesce due to apparent premature aging, most likely involving the accumulation of extrachromosomal rDNA circles [26].
  • Nijmegen breakage syndrome (NBS) is an autosomal genetic disease demonstrating a variety of phenotypic abnormalities, including premature aging, increased cancer incidence, chromosome instability, and sensitivity to ionizing radiation [27].
  • When wrn-1 expression was inhibited by RNA interference (RNAi), a slight reduction in C. elegans life span was observed, with accompanying signs of premature aging, such as earlier accumulation of lipofuscin and tissue deterioration in the head [28].
  • The addition of these genes increases the total to five helicase genes in the human RecQ family, which includes helicases involved in Bloom and Werner syndromes, the genetic diseases manifesting the distinctive but overlapping clinical phenotypes of immunodeficiency, premature aging, and an enhanced risk of cancer [29].

Analytical, diagnostic and therapeutic context of Aging, Premature


  1. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Sinclair, D.A., Mills, K., Guarente, L. Science (1997) [Pubmed]
  2. Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B. Stevnsner, T., Nyaga, S., de Souza-Pinto, N.C., van der Horst, G.T., Gorgels, T.G., Hogue, B.A., Thorslund, T., Bohr, V.A. Oncogene (2002) [Pubmed]
  3. Reducing mammary cancer risk through premature stem cell senescence. Boulanger, C.A., Smith, G.H. Oncogene (2001) [Pubmed]
  4. A MERRF/PEO overlap syndrome associated with the mitochondrial DNA 3243 mutation. Verma, A., Moraes, C.T., Shebert, R.T., Bradley, W.G. Neurology (1996) [Pubmed]
  5. The role of the nuclear envelope in cellular organization. D'Angelo, M.A., Hetzer, M.W. Cell. Mol. Life Sci. (2006) [Pubmed]
  6. Early glycoxidation damage in brains from Down's syndrome. Odetti, P., Angelini, G., Dapino, D., Zaccheo, D., Garibaldi, S., Dagna-Bricarelli, F., Piombo, G., Perry, G., Smith, M., Traverso, N., Tabaton, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  7. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Muñoz, P., Blanco, R., Flores, J.M., Blasco, M.A. Nat. Genet. (2005) [Pubmed]
  8. The Werner syndrome protein is a DNA helicase. Gray, M.D., Shen, J.C., Kamath-Loeb, A.S., Blank, A., Sopher, B.L., Martin, G.M., Oshima, J., Loeb, L.A. Nat. Genet. (1997) [Pubmed]
  9. Genomic instability in laminopathy-based premature aging. Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J.D., Li, K.M., Chau, P.Y., Chen, D.J., Pei, D., Pendas, A.M., Cadiñanos, J., López-Otín, C., Tse, H.F., Hutchison, C., Chen, J., Cao, Y., Cheah, K.S., Tryggvason, K., Zhou, Z. Nat. Med. (2005) [Pubmed]
  10. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Sun, L.Q., Lee, D.W., Zhang, Q., Xiao, W., Raabe, E.H., Meeker, A., Miao, D., Huso, D.L., Arceci, R.J. Genes Dev. (2004) [Pubmed]
  11. How do mutations in lamins A and C cause disease? Worman, H.J., Courvalin, J.C. J. Clin. Invest. (2004) [Pubmed]
  12. On signal sequence polymorphisms and diseases of distribution. Rosenblum, J.S., Gilula, N.B., Lerner, R.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Brain cell alterations suggesting premature aging induced by dietary deficiency of vitamin B6 and/or copper. Root, E.J., Longenecker, J.B. Am. J. Clin. Nutr. (1983) [Pubmed]
  14. Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. Poeggeler, B., Reiter, R.J., Tan, D.X., Chen, L.D., Manchester, L.C. J. Pineal Res. (1993) [Pubmed]
  15. Excess glucose intake induces accelerated beta-cell polyploidization in normal mice: a possible deleterious effect. White, J.W., Swartz, F.J., Swartz, A.F. J. Nutr. (1985) [Pubmed]
  16. Phenytoin-induced elevation of serum estradiol and reproductive dysfunction in men with epilepsy. Heroz, A.G., Levesque, L.A., Drislane, F.W., Ronthal, M., Schomer, D.L. Epilepsia (1991) [Pubmed]
  17. Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. Brosh, R.M., von Kobbe, C., Sommers, J.A., Karmakar, P., Opresko, P.L., Piotrowski, J., Dianova, I., Dianov, G.L., Bohr, V.A. EMBO J. (2001) [Pubmed]
  18. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A.T., Dufour, E., Khvorostov, I., Spelbrink, J.N., Wibom, R., Jacobs, H.T., Larsson, N.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  19. Gene expression profiling in Werner syndrome closely resembles that of normal aging. Kyng, K.J., May, A., Kølvraa, S., Bohr, V.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  20. Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts. Brenneisen, P., Wlaschek, M., Schwamborn, E., Schneider, L.A., Ma, W., Sies, H., Scharffetter-Kochanek, K. Biochem. J. (2002) [Pubmed]
  21. Molecular mechanisms of mitochondrial diabetes (MIDD). Maassen, J.A., Janssen, G.M., 't Hart, L.M. Ann. Med. (2005) [Pubmed]
  22. Skin changes in menopause. Bolognia, J.L., Braverman, I.M., Rousseau, M.E., Sarrel, P.M. Maturitas. (1989) [Pubmed]
  23. Sensorineural hearing disorders in systemic lupus erythematosus. A controlled study. Andonopoulos, A.P., Naxakis, S., Goumas, P., Lygatsikas, C. Clinical and experimental rheumatology. (1995) [Pubmed]
  24. Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene: a model for tongue pathology in Down's syndrome. Yarom, R., Sapoznikov, D., Havivi, Y., Avraham, K.B., Schickler, M., Groner, Y. J. Neurol. Sci. (1988) [Pubmed]
  25. Mutations in DNA replication genes reduce yeast life span. Hoopes, L.L., Budd, M., Choe, W., Weitao, T., Campbell, J.L. Mol. Cell. Biol. (2002) [Pubmed]
  26. The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. McVey, M., Kaeberlein, M., Tissenbaum, H.A., Guarente, L. Genetics (2001) [Pubmed]
  27. Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM. Bai, Y., Murnane, J.P. Mol. Cancer Res. (2003) [Pubmed]
  28. A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Lee, S.J., Yook, J.S., Han, S.M., Koo, H.S. Development (2004) [Pubmed]
  29. Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. Kitao, S., Ohsugi, I., Ichikawa, K., Goto, M., Furuichi, Y., Shimamoto, A. Genomics (1998) [Pubmed]
  30. Titers of murine leukemia virus are higher in brains of SAMP8 than SAMR1 mice. Meeker, H.C., Carp, R.I. Neurobiol. Aging (1997) [Pubmed]
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