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Gene Review

Itgb1  -  integrin beta 1 (fibronectin receptor beta)

Mus musculus

Synonyms: 4633401G24Rik, AA409975, AA960159, CD29, ENSMUSG00000051907, ...
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Disease relevance of Itgb1


High impact information on Itgb1


Chemical compound and disease context of Itgb1


Biological context of Itgb1


Anatomical context of Itgb1


Associations of Itgb1 with chemical compounds


Physical interactions of Itgb1


Enzymatic interactions of Itgb1


Regulatory relationships of Itgb1


Other interactions of Itgb1


Analytical, diagnostic and therapeutic context of Itgb1


  1. Targeted deletion of beta 1 integrins in F9 embryonal carcinoma cells affects morphological differentiation but not tissue-specific gene expression. Stephens, L.E., Sonne, J.E., Fitzgerald, M.L., Damsky, C.H. J. Cell Biol. (1993) [Pubmed]
  2. Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. Feltri, M.L., Graus Porta, D., Previtali, S.C., Nodari, A., Migliavacca, B., Cassetti, A., Littlewood-Evans, A., Reichardt, L.F., Messing, A., Quattrini, A., Mueller, U., Wrabetz, L. J. Cell Biol. (2002) [Pubmed]
  3. Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts. Brakebusch, C., Wennerberg, K., Krell, H.W., Weidle, U.H., Sallmyr, A., Johansson, S., Fässler, R. Oncogene (1999) [Pubmed]
  4. Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. Miura, K., Uniyal, S., Leabu, M., Oravecz, T., Chakrabarti, S., Morris, V.L., Chan, B.M. Biochem. Cell Biol. (2005) [Pubmed]
  5. Perturbation of beta1-integrin function alters the development of murine mammary gland. Faraldo, M.M., Deugnier, M.A., Lukashev, M., Thiery, J.P., Glukhova, M.A. EMBO J. (1998) [Pubmed]
  6. Deregulated expression of c-Myc depletes epidermal stem cells. Waikel, R.L., Kawachi, Y., Waikel, P.A., Wang, X.J., Roop, D.R. Nat. Genet. (2001) [Pubmed]
  7. Ligand binding regulates the directed movement of beta1 integrins on fibroblasts. Felsenfeld, D.P., Choquet, D., Sheetz, M.P. Nature (1996) [Pubmed]
  8. Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins. Hirsch, E., Iglesias, A., Potocnik, A.J., Hartmann, U., Fässler, R. Nature (1996) [Pubmed]
  9. Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Aszodi, A., Hunziker, E.B., Brakebusch, C., Fässler, R. Genes Dev. (2003) [Pubmed]
  10. Beta1 integrin mediates internalization of mammalian reovirus. Maginnis, M.S., Forrest, J.C., Kopecky-Bromberg, S.A., Dickeson, S.K., Santoro, S.A., Zutter, M.M., Nemerow, G.R., Bergelson, J.M., Dermody, T.S. J. Virol. (2006) [Pubmed]
  11. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Shai, S.Y., Harpf, A.E., Babbitt, C.J., Jordan, M.C., Fishbein, M.C., Chen, J., Omura, M., Leil, T.A., Becker, K.D., Jiang, M., Smith, D.J., Cherry, S.R., Loftus, J.C., Ross, R.S. Circ. Res. (2002) [Pubmed]
  12. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cos, S., Fernández, R., Güézmes, A., Sánchez-Barceló, E.J. Cancer Res. (1998) [Pubmed]
  13. Assessment of laminin-mediated glioma invasion in vitro and by glioma tumors engrafted within rat spinal cord. Muir, D., Johnson, J., Rojiani, M., Inglis, B.A., Rojiani, A., Maria, B.L. J. Neurooncol. (1996) [Pubmed]
  14. Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. Liu, S., Kapoor, M., Denton, C.P., Abraham, D.J., Leask, A. Arthritis Rheum. (2009) [Pubmed]
  15. Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. Wang, F., Hansen, R.K., Radisky, D., Yoneda, T., Barcellos-Hoff, M.H., Petersen, O.W., Turley, E.A., Bissell, M.J. J. Natl. Cancer Inst. (2002) [Pubmed]
  16. Genetic analysis of {beta}1 integrin "activation motifs" in mice. Czuchra, A., Meyer, H., Legate, K.R., Brakebusch, C., Fässler, R. J. Cell Biol. (2006) [Pubmed]
  17. Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. Li, N., Zhang, Y., Naylor, M.J., Schatzmann, F., Maurer, F., Wintermantel, T., Schuetz, G., Mueller, U., Streuli, C.H., Hynes, N.E. EMBO J. (2005) [Pubmed]
  18. Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation. Schwander, M., Shirasaki, R., Pfaff, S.L., Müller, U. J. Neurosci. (2004) [Pubmed]
  19. CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5. Finke, D., Acha-Orbea, H., Mattis, A., Lipp, M., Kraehenbuhl, J. Immunity (2002) [Pubmed]
  20. High glucose and angiotensin II increase beta1 integrin and integrin-linked kinase synthesis in cultured mouse podocytes. Han, S.Y., Kang, Y.S., Jee, Y.H., Han, K.H., Cha, D.R., Kang, S.W., Han, D.S. Cell Tissue Res. (2006) [Pubmed]
  21. Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with beta1 integrin mediated through the RGD site of CNR1. Mutoh, T., Hamada, S., Senzaki, K., Murata, Y., Yagi, T. Exp. Cell Res. (2004) [Pubmed]
  22. Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication. López-Rovira, T., Silva-Vargas, V., Watt, F.M. J. Invest. Dermatol. (2005) [Pubmed]
  23. Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Ip, J.E., Wu, Y., Huang, J., Zhang, L., Pratt, R.E., Dzau, V.J. Mol. Biol. Cell (2007) [Pubmed]
  24. Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. Barsukov, I.L., Prescot, A., Bate, N., Patel, B., Floyd, D.N., Bhanji, N., Bagshaw, C.R., Letinic, K., Di Paolo, G., De Camilli, P., Roberts, G.C., Critchley, D.R. J. Biol. Chem. (2003) [Pubmed]
  25. Beta1-integrins are critical for cerebellar granule cell precursor proliferation. Blaess, S., Graus-Porta, D., Belvindrah, R., Radakovits, R., Pons, S., Littlewood-Evans, A., Senften, M., Guo, H., Li, Y., Miner, J.H., Reichardt, L.F., Müller, U. J. Neurosci. (2004) [Pubmed]
  26. Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B. Arregui, C.O., Balsamo, J., Lilien, J. J. Cell Biol. (1998) [Pubmed]
  27. Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation. García, A.J., Vega, M.D., Boettiger, D. Mol. Biol. Cell (1999) [Pubmed]
  28. VLA-4 is involved in the engraftment of the human pre-B acute lymphoblastic leukaemia cell line NALM-6 in SCID mice. Filshie, R., Gottlieb, D., Bradstock, K. Br. J. Haematol. (1998) [Pubmed]
  29. Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit. Shaw, L.M., Mercurio, A.M. J. Cell Biol. (1993) [Pubmed]
  30. Integrin alpha1beta1 mediates collagen induction of MMP-13 expression in MC615 chondrocytes. Ronzière, M.C., Aubert-Foucher, E., Gouttenoire, J., Bernaud, J., Herbage, D., Mallein-Gerin, F. Biochim. Biophys. Acta (2005) [Pubmed]
  31. Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface. Salicioni, A.M., Gaultier, A., Brownlee, C., Cheezum, M.K., Gonias, S.L. J. Biol. Chem. (2004) [Pubmed]
  32. A chimeric N-cadherin/beta 1-integrin receptor which localizes to both cell-cell and cell-matrix adhesions. Geiger, B., Salomon, D., Takeichi, M., Hynes, R.O. J. Cell. Sci. (1992) [Pubmed]
  33. Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. Pankov, R., Cukierman, E., Clark, K., Matsumoto, K., Hahn, C., Poulin, B., Yamada, K.M. J. Biol. Chem. (2003) [Pubmed]
  34. Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. Hirsch, E., Barberis, L., Brancaccio, M., Azzolino, O., Xu, D., Kyriakis, J.M., Silengo, L., Giancotti, F.G., Tarone, G., Fässler, R., Altruda, F. J. Cell Biol. (2002) [Pubmed]
  35. Epidermal growth factor activation of vinculin and beta 1-integrin gene transcription in quiescent Swiss 3T3 cells. Regulation through a protein kinase C-independent pathway. Bellas, R.E., Bendori, R., Farmer, S.R. J. Biol. Chem. (1991) [Pubmed]
  36. Notch, epidermal growth factor receptor, and beta1-integrin pathways are coordinated in neural stem cells. Campos, L.S., Decker, L., Taylor, V., Skarnes, W. J. Biol. Chem. (2006) [Pubmed]
  37. Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro. Falk, M., Salmivirta, K., Durbeej, M., Larsson, E., Ekblom, M., Vestweber, D., Ekblom, P. J. Cell. Sci. (1996) [Pubmed]
  38. Beta 1/beta 3 integrin ligation is uncoupled from ERK1/ERK2 activation in cytotoxic T lymphocytes. Puente, L.G., Ostergaard, H.L. J. Leukoc. Biol. (2003) [Pubmed]
  39. Interstitial remodeling in beta1-adrenergic receptor transgenic mice. Seeland, U., Selejan, S., Engelhardt, S., Müller, P., Lohse, M.J., Böhm, M. Basic Res. Cardiol. (2007) [Pubmed]
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