The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Slc13a2  -  solute carrier family 13 (sodium-dependent...

Mus musculus

Synonyms: Na(+)/dicarboxylate cotransporter 1, NaDC-1, Nadc1, Renal sodium/dicarboxylate cotransporter, Sdct1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Slc13a2

  • The Na(+)/dicarboxylate cotransporters (NaDC1) from mouse (m) and rabbit (rb) differ in their ability to handle glutarate [1].
  • We conclude that TM 3 and 4 contain amino acid residues that are important determinants of substrate specificity and catalytic efficiency in NaDC1 [1].
  • The sodium-dicarboxylate cotransporter of the renal proximal tubule, NaDC-1, reabsorbs filtered Krebs cycle intermediates and plays an important role in the regulation of urinary citrate concentrations [2].
  • Expression of mNaDC-1 in Xenopus laevis oocytes results in increased transport of di- and tricarboxylates [2].
  • The gene coding for mNaDC-1, Slc13a2, is found on chromosome 11 [2].
 

Anatomical context of Slc13a2

 

Associations of Slc13a2 with chemical compounds

  • We conclude that multiple amino acids from TM 8, 9 and 10 contribute to the transport of adipate in NaDC1 [3].

References

  1. Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1. Oshiro, N., King, S.C., Pajor, A.M. Biochemistry (2006) [Pubmed]
  2. Molecular cloning, chromosomal organization, and functional characterization of a sodium-dicarboxylate cotransporter from mouse kidney. Pajor, A.M., Sun, N.N. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  3. Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter. Oshiro, N., Pajor, A.M. Biochim. Biophys. Acta (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities