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Gene Review

Slc13a2  -  solute carrier family 13 (sodium-dependent...

Mus musculus

Synonyms: Na(+)/dicarboxylate cotransporter 1, NaDC-1, Nadc1, Renal sodium/dicarboxylate cotransporter, Sdct1, ...
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High impact information on Slc13a2

  • The Na(+)/dicarboxylate cotransporters (NaDC1) from mouse (m) and rabbit (rb) differ in their ability to handle glutarate [1].
  • We conclude that TM 3 and 4 contain amino acid residues that are important determinants of substrate specificity and catalytic efficiency in NaDC1 [1].
  • The sodium-dicarboxylate cotransporter of the renal proximal tubule, NaDC-1, reabsorbs filtered Krebs cycle intermediates and plays an important role in the regulation of urinary citrate concentrations [2].
  • Expression of mNaDC-1 in Xenopus laevis oocytes results in increased transport of di- and tricarboxylates [2].
  • The gene coding for mNaDC-1, Slc13a2, is found on chromosome 11 [2].

Anatomical context of Slc13a2


Associations of Slc13a2 with chemical compounds

  • We conclude that multiple amino acids from TM 8, 9 and 10 contribute to the transport of adipate in NaDC1 [3].


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