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Gene Review

EPHB6  -  EPH receptor B6

Homo sapiens

Synonyms: Ephrin type-B receptor 6, HEP, Tyrosine-protein kinase-defective receptor EPH-6
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Disease relevance of EPHB6

  • Taken together, these analyses show that EPHB6 is a metastasis inhibitory gene that is frequently silenced by hypermethylation of its promoter in NSCLC [1].

High impact information on EPHB6

  • Transfection of EPHB6 cDNA into IMR5 and SY5Y expressing little endogenous EPHB6 resulted in inhibition of their clonogenicity in culture [2].
  • Peroxide production after stimulation with phorbol myristic acid could be induced by LK, LK with anti-IFN-gamma antibody, 5637, and SK-HEP treatment [3].
  • SK-HEP and 5637 CM had strong chemotactic peptide receptor-inducing activity, but human CSF-1 was inactive up to 800 units/ml [3].
  • Other sources of Fc receptor-inducing activity were CM from SK-HEP and 5637 cell lines [3].
  • Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration [4].

Biological context of EPHB6

  • However, six invariant amino acids such as a lysine in the ATP-binding site and an aspartic acid in the phosphotransfer site of a conserved catalytic domain were substituted with other amino acid residues in HEP [5].
  • Moreover, after a 30-min incubation of S-1-HEP with hEST, 95% of the recovered alcohol showed the R-configuration, indicating that several cycles of sulfation and hydrolysis had led to the depletion of one enantiomer and to the enrichment of the other enantiomer [6].

Other interactions of EPHB6

  • Higher levels of EPHB6, EFNB2, and EFNB3 expression were found in low-stage tumors (stage 1, 2, and 4S) than in advanced-stage tumors (stage 3 and 4; P = 0.0013, P = 0.0048, and P = 0.027, respectively) [7].


  1. The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer. Yu, J., Bulk, E., Ji, P., Hascher, A., Tang, M., Metzger, R., Marra, A., Serve, H., Berdel, W.E., Wiewroth, R., Koschmieder, S., Müller-Tidow, C. Clin. Cancer Res. (2010) [Pubmed]
  2. Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma. Tang, X.X., Zhao, H., Robinson, M.E., Cohen, B., Cnaan, A., London, W., Cohn, S.L., Cheung, N.K., Brodeur, G.M., Evans, A.E., Ikegaki, N. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Distinct activities of interferon-gamma, lymphokine and cytokine differentiation-inducing factors acting on the human monoblastic leukemia cell line U937. Harris, P.E., Ralph, P., Litcofsky, P., Moore, M.A. Cancer Res. (1985) [Pubmed]
  4. Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. Matsuoka, H., Obama, H., Kelly, M.L., Matsui, T., Nakamoto, M. J. Biol. Chem. (2005) [Pubmed]
  5. Expression of a kinase-defective Eph-like receptor in the normal human brain. Matsuoka, H., Iwata, N., Ito, M., Shimoyama, M., Nagata, A., Chihara, K., Takai, S., Matsui, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  6. Chiral inversion of 1-hydroxyethylpyrene enantiomers mediated by enantioselective sulfotransferases. Landsiedel, R., Pabel, U., Engst, W., Ploschke, J., Seidel, A., Glatt, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  7. High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas. Tang, X.X., Evans, A.E., Zhao, H., Cnaan, A., London, W., Cohn, S.L., Brodeur, G.M., Ikegaki, N. Clin. Cancer Res. (1999) [Pubmed]
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