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Gene Review

SULT1E1  -  sulfotransferase family 1E, estrogen...

Homo sapiens

Synonyms: EST, EST-1, Estrogen sulfotransferase, ST1E1, STE, ...
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Disease relevance of SULT1E1


Psychiatry related information on SULT1E1

  • The potential correlation between alcohol consumption and hepatic EST expression deserves further evaluation [5].
  • One EST was mapped within the critical region for Rieger syndrome type 2, and three transcripts were identified in the region for the nocturnal enuresis type 1 [6].
  • Fine mapping of 12 previously unassigned EST clones to individual YACs in the familial Alzheimer's disease (FAD) region of chromosome 14q24.3 [7].
  • Eighty-nine volunteer subjects completed a test anxiety scale (TAS) and an effective study test (EST) at the beginning of the spring semester [8].
  • These EST-related resistance mechanisms could be used in investigations into the defense mechanisms of wild species, and to provide new routes to improving the germplasm of cultivated rice [9].

High impact information on SULT1E1

  • During the last five years, the development of bioinformatics and EST databases has been primarily responsible for the identification of many new chemokines and chemokine receptors [10].
  • The protein is predicted to consist of 12 transmembrane domains and is 55% identical to a human EST of unknown function isolated from melanocytes and melanoma cells [11].
  • More than 1.6 million human EST sequences have been deposited in public databases, making it difficult to identify ESTs that represent new genes [12].
  • Using highly refined and tested algorithms for EST analysis, we have arrived at two independent estimates indicating the human genome contains approximately 120,000 genes [13].
  • This is exemplified by the in silico cloning (prediction of a gene product sequence using only genomic and EST sequence data) of a new type of GTPase with two catalytic domains [12].

Chemical compound and disease context of SULT1E1


Biological context of SULT1E1


Anatomical context of SULT1E1


Associations of SULT1E1 with chemical compounds

  • T1AM, the most active thyronamine pharmacologically, was associated with the greatest SULT activity of the thyronamines tested in the liver pool and in both the expressed SULT1A3 and SULT1E1 preparations [26].
  • Moreover, when estrone (which selectively inhibits expressed SULT1E1 and SULT1A3) was included in intestinal incubations, the high-affinity component of the Eadie-Hofstee plot for EE sulfation was inhibited, converting the plot from biphasic to monophasic [27].
  • SULT1E1, a member of the phenol sulfotransferase family, used 3,3'-T(2) and rT(3) more readily than T(3), and also displayed the greatest specificity for T(4) among human SULTs [28].
  • Liver pool (n=5) SULT activities measured with tibolone substrates reflected COS-1 expressed SULT2A1 and SULT1E1 activities [29].
  • SULT1E1 was the only isoform exhibiting detectable levels of raloxifene disulfation activity [19].

Physical interactions of SULT1E1


Enzymatic interactions of SULT1E1


Regulatory relationships of SULT1E1


Other interactions of SULT1E1


Analytical, diagnostic and therapeutic context of SULT1E1


  1. Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone. Falany, J.L., Falany, C.N. Endocrinology (1996) [Pubmed]
  2. Expression of human estrogen sulfotransferase in Salmonella typhimurium: differences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen. Hagen, M., Pabel, U., Landsiedel, R., Bartsch, I., Falany, C.N., Glatt, H. Chem. Biol. Interact. (1998) [Pubmed]
  3. New development in intracrinology of breast carcinoma. Sasano, H., Suzuki, T., Nakata, T., Moriya, T. Breast Cancer (2006) [Pubmed]
  4. Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma. Suzuki, T., Nakata, T., Miki, Y., Kaneko, C., Moriya, T., Ishida, T., Akinaga, S., Hirakawa, H., Kimura, M., Sasano, H. Cancer Res. (2003) [Pubmed]
  5. Estrogen sulfotransferase expression in the human liver: marked interindividual variation and lack of gender specificity. Song, W.C., Qian, Y., Li, A.P. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  6. Identification of positional candidates for neurological disorders on chromsome 13q14-->q22. Nothwang, H.G., Wirth, J., Brandl, B., Haaf, T., Nielsen, K.B., Tommerup, N., Ropers, H.H. Cytogenet. Cell Genet. (1997) [Pubmed]
  7. Fine mapping of 12 previously unassigned EST clones to individual YACs in the familial Alzheimer's disease (FAD) region of chromosome 14q24.3. Ardley, H.C., Markham, A.F., Robinson, P.A. Cytogenet. Cell Genet. (1998) [Pubmed]
  8. Test anxiety. Relationship to academic and clinical performance in dental hygiene students. Rich, S.K. Journal of dental hygiene : JDH / American Dental Hygienists' Association. (1991) [Pubmed]
  9. Identification of genes induced in wound-treated wild rice (Oryza minuta). Cho, S.K., Jeung, J.U., Kang, K.H., Shim, K.S., Jung, K.W., You, M.K., Ok, S.H., Chung, Y.S., Hwang, H.G., Choi, H.C., Moon, H.P., Shin, J.S. Mol. Cells (2004) [Pubmed]
  10. The biology of chemokines and their receptors. Rossi, D., Zlotnik, A. Annu. Rev. Immunol. (2000) [Pubmed]
  11. Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka. Fukamachi, S., Shimada, A., Shima, A. Nat. Genet. (2001) [Pubmed]
  12. More than 1,000 putative new human signalling proteins revealed by EST data mining. Schultz, J., Doerks, T., Ponting, C.P., Copley, R.R., Bork, P. Nat. Genet. (2000) [Pubmed]
  13. Gene index analysis of the human genome estimates approximately 120,000 genes. Liang, F., Holt, I., Pertea, G., Karamycheva, S., Salzberg, S.L., Quackenbush, J. Nat. Genet. (2000) [Pubmed]
  14. Cloning and expression of cDNA encoding human placental estrogen sulfotransferase. Bernier, F., Lopez Solache, I., Labrie, F., Luu-The, V. Mol. Cell. Endocrinol. (1994) [Pubmed]
  15. Regulation of SULT1E1 expression in Ishikawa adenocarcinoma cells by tibolone. Falany, J.L., Falany, C.N. Steroids (2006) [Pubmed]
  16. High metabolization of catecholestrogens by type 1 estrogen sulfotransferase (hEST1). Faucher, F., Lacoste, L., Dufort, I., Luu-The, V. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  17. Human estrogen sulfotransferase (hEST1) activities and its mRNA in various breast cancer cell lines. Effect of the progestin, promegestone (R-5020). Chetrite, G., Le Nestour, E., Pasqualini, J.R. J. Steroid Biochem. Mol. Biol. (1998) [Pubmed]
  18. Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. Meinl, W., Glatt, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  19. Sulfation of raloxifene and 4-hydroxytamoxifen by human cytosolic sulfotransferases. Falany, J.L., Pilloff, D.E., Leyh, T.S., Falany, C.N. Drug Metab. Dispos. (2006) [Pubmed]
  20. Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Rubin, G.L., Harrold, A.J., Mills, J.A., Falany, C.N., Coughtrie, M.W. Mol. Hum. Reprod. (1999) [Pubmed]
  21. Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. Her, C., Aksoy, I.A., Kimura, S., Brandriff, B.F., Wasmuth, J.J., Weinshilboum, R.M. Genomics (1995) [Pubmed]
  22. Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. Aksoy, I.A., Wood, T.C., Weinshilboum, R. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  23. Redox regulation of human estrogen sulfotransferase (hSULT1E1). Maiti, S., Zhang, J., Chen, G. Biochem. Pharmacol. (2007) [Pubmed]
  24. Molecular biology of the human cytosolic sulfotransferase gene superfamily implicated in the bioactivation of minoxidil and cholesterol in skin. Dooley, T.P. Exp. Dermatol. (1999) [Pubmed]
  25. Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation. Her, C., Szumlanski, C., Aksoy, I.A., Weinshilboum, R.M. Drug Metab. Dispos. (1996) [Pubmed]
  26. Thyronamines are substrates for human liver sulfotransferases. Pietsch, C.A., Scanlan, T.S., Anderson, R.J. Endocrinology (2007) [Pubmed]
  27. Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol. Schrag, M.L., Cui, D., Rushmore, T.H., Shou, M., Ma, B., Rodrigues, A.D. Drug Metab. Dispos. (2004) [Pubmed]
  28. Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases. Li, X., Anderson, R.J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  29. Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Wang, M., Ebmeier, C.C., Olin, J.R., Anderson, R.J. Steroids (2006) [Pubmed]
  30. Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells. Lewis, A.J., Walle, U.K., King, R.S., Kadlubar, F.F., Falany, C.N., Walle, T. Carcinogenesis (1998) [Pubmed]
  31. Metabolic activation of methyl-hydroxylated derivatives of 7,12-dimethylbenz[a]anthracene by human liver dehydroepiandrosterone-steroid sulfotransferase. Chou, H.C., Ozawa, S., Fu, P.P., Lang, N.P., Kadlubar, F.F. Carcinogenesis (1998) [Pubmed]
  32. Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer. Choi, J.Y., Lee, K.M., Park, S.K., Noh, D.Y., Ahn, S.H., Chung, H.W., Han, W., Kim, J.S., Shin, S.G., Jang, I.J., Yoo, K.Y., Hirvonen, A., Kang, D. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
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