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Gene Review

EFNB3  -  ephrin-B3

Homo sapiens

Synonyms: EFL6, EPH-related receptor transmembrane ligand ELK-L3, EPH-related receptor tyrosine kinase ligand 8, EPLG8, Ephrin-B3, ...
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Disease relevance of EFNB3


High impact information on EFNB3


Biological context of EFNB3


Anatomical context of EFNB3


Other interactions of EFNB3

  • Taken together, these data indicate that the expression of EPHB6, EFNB2, and EFNB3 may serve as prognostic indicators of favorable NBs [8].
  • Since the novel gene is the eighth member of the EPLG gene family, it is designated EPLG8 [6].
  • Multiple receptors were primarily identified on DPSCs within the perivascular niche, whereas ephrin-B1 and ephrin-B3 were expressed by the surrounding pulp tissue [9].


  1. Prognostic significance of EPHB6, EFNB2, and EFNB3 expressions in neuroblastoma. Tang, X.X., Zhao, H., Robinson, M.E., Cnaan, A., London, W., Cohn, S.L., Cheung, N.K., Brodeur, G.M., Evans, A.E., Ikegaki, N. Med. Pediatr. Oncol. (2000) [Pubmed]
  2. Comparative integromics on Ephrin family. Katoh, Y., Katoh, M. Oncol. Rep. (2006) [Pubmed]
  3. Ephrin-B3 Ligand Promotes Glioma Invasion through Activation of Rac1. Nakada, M., Drake, K.L., Nakada, S., Niska, J.A., Berens, M.E. Cancer Res. (2006) [Pubmed]
  4. High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas. Tang, X.X., Evans, A.E., Zhao, H., Cnaan, A., London, W., Cohn, S.L., Brodeur, G.M., Ikegaki, N. Clin. Cancer Res. (1999) [Pubmed]
  5. Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro. Takemoto, M., Fukuda, T., Sonoda, R., Murakami, F., Tanaka, H., Yamamoto, N. Eur. J. Neurosci. (2002) [Pubmed]
  6. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors. Tang, X.X., Pleasure, D.E., Ikegaki, N. Genomics (1997) [Pubmed]
  7. Ephrin B1 is expressed on human luteinizing granulosa cells in corpora lutea of the early luteal phase: the possible involvement of the B class Eph-ephrin system during corpus luteum formation. Egawa, M., Yoshioka, S., Higuchi, T., Sato, Y., Tatsumi, K., Fujiwara, H., Fujii, S. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  8. Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas. Tang, X.X., Evans, A.E., Zhao, H., Cnaan, A., Brodeur, G.M., Ikegaki, N. Med. Pediatr. Oncol. (2001) [Pubmed]
  9. EphB/Ephrin-B Interaction Mediates Adult Stem Cell Attachment, Spreading, and Migration: Implications for Dental Tissue Repair. Stokowski, A., Shi, S., Sun, T., Bartold, P.M., Koblar, S.A., Gronthos, S. Stem Cells (2007) [Pubmed]
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