Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SENP5 - SUMO1/sentrin specific peptidase 5

Homo sapiens

Synonyms: FKSG45, MGC27076, Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5

Gong, L. et al., Di Bacco, A. et al., Zunino, R. et al., Di Bacco, A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SENP5

The SUMO-specific protease SENP5 is required for cell division [1].
Nonetheless, SENP5 could remove SUMO-1, -2, and -3 from the Lys65 position of PML [2].
SENP5 showed SUMO-3 C-terminal hydrolase activity but could not process pro-SUMO-1 in vitro [2].
We were also able to show that SENP3 has substrate specificity similar to that of SENP5 [2].
Here, we have described SENP5, which has restricted substrate specificity [2].

Biological context of SENP5

Overexpression of SENP5 rescues SUMO1-induced mitochondrial fragmentation that is partly due to the downregulation of DRP1 [3].
Furthermore, our finding of a nonredundant function for SENP5 in cell proliferation provides further support for the model that, analogous to phosphorylation, cycles of SUMOylation and deSUMOylation regulate orderly progression through cell division [4].
SUMO-specific proteases and the cell cycle. An essential role for SENP5 in cell proliferation [4].

Other interactions of SENP5

Thus, SENP5 also possesses limited SUMO-1 isopeptidase activity [2].

References

The SUMO-specific protease SENP5 is required for cell division. Di Bacco, A., Ouyang, J., Lee, H.Y., Catic, A., Ploegh, H., Gill, G. Mol. Cell. Biol. (2006) [Pubmed]
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. Gong, L., Yeh, E.T. J. Biol. Chem. (2006) [Pubmed]
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. Zunino, R., Schauss, A., Rippstein, P., Andrade-Navarro, M., McBride, H.M. J. Cell. Sci. (2007) [Pubmed]
SUMO-specific proteases and the cell cycle. An essential role for SENP5 in cell proliferation. Di Bacco, A., Gill, G. Cell Cycle (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SENP5	Bos taurus
SENP5	Canis lupus familiaris
SENP5	Gallus gallus
SENP5	Macaca mulatta
Senp5	Mus musculus
SENP5	Pan troglodytes
Senp5	Rattus norvegicus
LOC690251	Rattus norvegicus
RGD1564247	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.