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Gene Review

Snrnp70  -  small nuclear ribonucleoprotein 70 (U1)

Mus musculus

Synonyms: 2700022N21Rik, 3200002N22Rik, AI325098, R74807, Rnu1p70, ...
 
 
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Disease relevance of Snrp70

 

High impact information on Snrp70

  • Last, antibodies directed against U1-70 kd arose spontaneously in granzyme B-deficient mice [3].
  • Thus, a major epitope in the B cell response to U1-70 kDa localizes to the RNA binding domain of the molecule, overlaps with the most common T cell epitope in the anti-70k response, and is not present on the intact form of the 70k molecule [4].
  • We also found evidence that a highly conserved amino acid sequence, which is shared by p30 and U1 small nuclear ribonucleoprotein 70-kDa protein, is a component of the nuclear targeting sequence for Pr65gag [5].
  • Ad-gB induced a significant IgG autoantibody response (p > 0.005) to the U1-70 kDa spliceosome protein in both autoimmune and normal strains whereas immunization with recombinant human La/SS-B did not [1].
  • We further compared U1-70kDa and poly(ADP-ribose) polymerase cleavage in stably Bcl-2 transfected RAW 264.7 macrophages [6].
 

Biological context of Snrp70

References

  1. Recombinant cytomegalovirus glycoprotein gB (UL55) induces an autoantibody response to the U1-70 kDa small nuclear ribonucleoprotein. Curtis, H.A., Singh, T., Newkirk, M.M. Eur. J. Immunol. (1999) [Pubmed]
  2. The genotype of mice influences the autoimmune response to spliceosome proteins induced by cytomegalovirus gB immunization. Lipes, J., Skamene, E., Newkirk, M.M. Clin. Exp. Immunol. (2002) [Pubmed]
  3. Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. Graham, K.L., Thibault, D.L., Steinman, J.B., Okeke, L., Kao, P.N., Utz, P.J. Arthritis Rheum. (2005) [Pubmed]
  4. A major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein autoantigen. Greidinger, E.L., Foecking, M.F., Magee, J., Wilson, L., Ranatunga, S., Ortmann, R.A., Hoffman, R.W. J. Immunol. (2004) [Pubmed]
  5. A subset of Pr65gag is nucleus associated in murine leukemia virus-infected cells. Nash, M.A., Meyer, M.K., Decker, G.L., Arlinghaus, R.B. J. Virol. (1993) [Pubmed]
  6. Protease activation during nitric oxide-induced apoptosis: comparison between poly(ADP-ribose) polymerase and U1-70kDa cleavage. Messmer, U.K., Reimer, D.M., Brüne, B. Eur. J. Pharmacol. (1998) [Pubmed]
 
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