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Gene Review

ESRRG  -  estrogen-related receptor gamma

Homo sapiens

Synonyms: ERR gamma-2, ERR3, ERRG2, ERRgamma, Estrogen receptor-related protein 3, ...
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Disease relevance of ESRRG


High impact information on ESRRG


Biological context of ESRRG


Anatomical context of ESRRG


Associations of ESRRG with chemical compounds

  • However, 4-hydroxytamoxifen and diethylstilbestrol were recently shown to bind to and inhibit ERRgamma activity [7].
  • A conserved AF-2 activation domain located in the hormone-binding domain of ERR3 was primarily responsible for transcriptional activation [6].
  • Similarly, in the orphan nuclear receptor called estrogen-related receptor 3 (ERR3), the replacement of Asp-273 (the corresponding amino acid to Asp-351 in ERalpha) with lysine abolished constitutive transcriptional activity of ERR3 without affecting DNA-binding activity and impaired the ability of the receptor to interact with p160 coactivators [10].
  • In contrast, ERRgamma activates transcription at AP-1 sites in the presence of 4OHT and 4OHtor [8].
  • Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERRgamma) with high constitutive activity [9].

Regulatory relationships of ESRRG


Other interactions of ESRRG


Analytical, diagnostic and therapeutic context of ESRRG


  1. Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Ariazi, E.A., Clark, G.M., Mertz, J.E. Cancer Res. (2002) [Pubmed]
  2. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. Hentschke, M., Borgmeyer, U. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Greschik, H., Wurtz, J.M., Sanglier, S., Bourguet, W., van Dorsselaer, A., Moras, D., Renaud, J.P. Mol. Cell (2002) [Pubmed]
  4. 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma. Coward, P., Lee, D., Hull, M.V., Lehmann, J.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. X-ray Crystal Structures of the Estrogen-related Receptor-{gamma} Ligand Binding Domain in Three Functional States Reveal the Molecular Basis of Small Molecule Regulation. Wang, L., Zuercher, W.J., Consler, T.G., Lambert, M.H., Miller, A.B., Orband-Miller, L.A., McKee, D.D., Willson, T.M., Nolte, R.T. J. Biol. Chem. (2006) [Pubmed]
  6. Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. Hong, H., Yang, L., Stallcup, M.R. J. Biol. Chem. (1999) [Pubmed]
  7. Dimerization modulates the activity of the orphan nuclear receptor ERRgamma. Huppunen, J., Aarnisalo, P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  8. Requirements for transcriptional regulation by the orphan nuclear receptor ERRgamma. Huppunen, J., Wohlfahrt, G., Aarnisalo, P. Mol. Cell. Endocrinol. (2004) [Pubmed]
  9. Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERRgamma) with high constitutive activity. Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Shimohigashi, Y. Toxicol. Lett. (2006) [Pubmed]
  10. Role of aspartate 351 in transactivation and active conformation of estrogen receptor alpha. Kim, J.H., Lee, M.H., Kim, B.J., Kim, J.H., Han, S.J., Kim, H.Y., Stallcup, M.R. J. Mol. Endocrinol. (2005) [Pubmed]
  11. Simulation of the different biological activities of diethylstilbestrol (DES) on estrogen receptor alpha and estrogen-related receptor gamma. Nam, K., Marshall, P., Wolf, R.M., Cornell, W. Biopolymers (2003) [Pubmed]
  12. Cellular Localization Studies on Human Estrogen Sulfotransferase SULT1E1 in Human Embryonic Kidney 293 Cells. Kapoor, R., Nimmagadda, D., Sheng, J.J. Drug Metab. Dispos. (2007) [Pubmed]
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