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Gene Review

NRIP1  -  nuclear receptor interacting protein 1

Homo sapiens

Synonyms: Nuclear factor RIP140, Nuclear receptor-interacting protein 1, RIP140, Receptor-interacting protein 140
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Disease relevance of NRIP1


High impact information on NRIP1


Chemical compound and disease context of NRIP1


Biological context of NRIP1


Anatomical context of NRIP1


Associations of NRIP1 with chemical compounds


Physical interactions of NRIP1


Regulatory relationships of NRIP1


Other interactions of NRIP1


Analytical, diagnostic and therapeutic context of NRIP1


  1. Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis. Morón, F.J., Mendoza, N., Vázquez, F., Molero, E., Quereda, F., Salinas, A., Fontes, J., Martínez-Astorquiza, T., Sánchez-Borrego, R., Ruiz, A. Bone (2006) [Pubmed]
  2. Transcriptional regulation of the human NRIP1/RIP140 gene by estrogen is modulated by dioxin signalling. Augereau, P., Badia, E., Fuentes, M., Rabenoelina, F., Corniou, M., Derocq, D., Balaguer, P., Cavailles, V. Mol. Pharmacol. (2006) [Pubmed]
  3. Preliminary molecular genetic analysis of the Receptor Interacting Protein 140 (RIP140) in women affected by endometriosis. Caballero, V., Ruiz, R., Sainz, J.A., Cruz, M., López-Nevot, M.A., Galán, J.J., Real, L.M., de Castro, F., López-Villaverde, V., Ruiz, A. J. Exp. Clin. Assist. Reprod. (2005) [Pubmed]
  4. Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions. Zhao, H.H., Herrera, R.E., Coronado-Heinsohn, E., Yang, M.C., Ludes-Meyers, J.H., Seybold-Tilson, K.J., Nawaz, Z., Yee, D., Barr, F.G., Diab, S.G., Brown, P.H., Fuqua, S.A., Osborne, C.K. J. Biol. Chem. (2001) [Pubmed]
  5. Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation. Mostaqul Huq, M.D., Gupta, P., Tsai, N.P., White, R., Parker, M.G., Wei, L.N. EMBO J. (2006) [Pubmed]
  6. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. Cavaillès, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P.J., Parker, M.G. EMBO J. (1995) [Pubmed]
  7. Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid. White, K.A., Yore, M.M., Deng, D., Spinella, M.J. J. Biol. Chem. (2005) [Pubmed]
  8. Transcriptional activation of the nuclear receptor corepressor RIP140 by retinoic acid: a potential negative-feedback regulatory mechanism. Kerley, J.S., Olsen, S.L., Freemantle, S.J., Spinella, M.J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  9. Apparent coactivation due to interference of expression constructs with nuclear receptor expression. Hofman, K., Swinnen, J.V., Claessens, F., Verhoeven, G., Heyns, W. Mol. Cell. Endocrinol. (2000) [Pubmed]
  10. The oestrogen receptor regulates NFkappaB and AP-1 activity in a cell-specific manner. Cerillo, G., Rees, A., Manchanda, N., Reilly, C., Brogan, I., White, A., Needham, M. J. Steroid Biochem. Mol. Biol. (1998) [Pubmed]
  11. Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha. Miyata, K.S., McCaw, S.E., Meertens, L.M., Patel, H.V., Rachubinski, R.A., Capone, J.P. Mol. Cell. Endocrinol. (1998) [Pubmed]
  12. Receptor-interacting protein 140 is a repressor of the androgen receptor activity. Carascossa, S., Gobinet, J., Georget, V., Lucas, A., Badia, E., Castet, A., White, R., Nicolas, J.C., Cavaillès, V., Jalaguier, S. Mol. Endocrinol. (2006) [Pubmed]
  13. Receptor-interacting protein 140 binds c-Jun and inhibits estradiol-induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. Teyssier, C., Belguise, K., Galtier, F., Cavailles, V., Chalbos, D. Mol. Endocrinol. (2003) [Pubmed]
  14. Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. Tazawa, H., Osman, W., Shoji, Y., Treuter, E., Gustafsson, J.A., Zilliacus, J. Mol. Cell. Biol. (2003) [Pubmed]
  15. The nuclear-receptor interacting protein (RIP) 140 binds to the human glucocorticoid receptor and modulates hormone-dependent transactivation. Windahl, S.H., Treuter, E., Ford, J., Zilliacus, J., Gustafsson, J.A., McEwan, I.J. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  16. Real-time analysis of molecular interaction of retinoid receptors and receptor-interacting protein 140 (RIP140). Chen, Y., Kerimo, A., Khan, S., Wei, L.N. Mol. Endocrinol. (2002) [Pubmed]
  17. Regulation of co-repressive activity of and HDAC recruitment to RIP140 by site-specific phosphorylation. Gupta, P., Huq, M.D., Khan, S.A., Tsai, N.P., Wei, L.N. Mol. Cell Proteomics (2005) [Pubmed]
  18. Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes. Castet, A., Herledan, A., Bonnet, S., Jalaguier, S., Vanacker, J.M., Cavaillès, V. Mol. Endocrinol. (2006) [Pubmed]
  19. SUMOylation modulates the transcription repressor function of RIP140. Rytinki, M.M., Palvimo, J.J. J. Biol. Chem. (2008) [Pubmed]
  20. Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Castet, A., Boulahtouf, A., Versini, G., Bonnet, S., Augereau, P., Vignon, F., Khochbin, S., Jalaguier, S., Cavaillès, V. Nucleic Acids Res. (2004) [Pubmed]
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