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Gene Review

Tfdp2  -  transcription factor Dp 2

Mus musculus

Synonyms: 1110029I05Rik, A330080J22Rik, DP-3, DP3, Dp-3, ...
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Disease relevance of Tfdp2


High impact information on Tfdp2

  • E2F4 nuclear accumulation is induced by the binding in the cytoplasm with specific partners p107, pRb2/p130, and DP3delta, an nls-containing spliced form of DP3, which provide the nls [2].
  • FAK re-expressing fibroblasts (clones DA2 and DP3) exhibit a characteristic fibrillar shape and display indistinguishable FN receptor-stimulated migration properties compared to normal fibroblasts [3].
  • Peptides derived from the group 2 allergen of Dermatophagoides pteronyssinus, Dp2 28-40 and Dp2 28-40A, and fungal immunomodulatory peptide (FIP) have been shown to act as T(H)1 potential and response-inducing adjuvant [4].
  • When lung function was measured after therapy, early phase airway hypersensitivity to methacholine significantly suppressed by Dp2 NT, while late phase hypersensitivity was suppressed but not to a significant level [1].

Analytical, diagnostic and therapeutic context of Tfdp2

  • Efficacy of local nasal immunotherapy for Dp2-induced airway inflammation in mice: Using Dp2 peptide and fungal immunomodulatory peptide [4].


  1. Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator. Liu, Y.H., Tsai, C.F., Kao, M.C., Lai, Y.L., Tsai, J.J. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. (2003) [Pubmed]
  2. Regulation of E2F4 mitogenic activity during terminal differentiation by its heterodimerization partners for nuclear translocation. Puri, P.L., Cimino, L., Fulco, M., Zimmerman, C., La Thangue, N.B., Giordano, A., Graessmann, A., Levrero, M. Cancer Res. (1998) [Pubmed]
  3. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. Sieg, D.J., Hauck, C.R., Schlaepfer, D.D. J. Cell. Sci. (1999) [Pubmed]
  4. Efficacy of local nasal immunotherapy for Dp2-induced airway inflammation in mice: Using Dp2 peptide and fungal immunomodulatory peptide. Liu, Y.H., Kao, M.C., Lai, Y.L., Tsai, J.J. J. Allergy Clin. Immunol. (2003) [Pubmed]
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