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Gene Review

TFDP2  -  transcription factor Dp-2 (E2F...

Homo sapiens

Synonyms: DP2, Dp-2, E2F dimerization partner 2, Transcription factor Dp-2
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Disease relevance of TFDP2


High impact information on TFDP2

  • E2F4 and DP2 interact through an extensive protein-protein interface, and structural features of this interface suggest it contributes to the preference for heterodimers over homodimers in DNA binding [4].
  • DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo [5].
  • Our data also strongly suggest that the 55-kDa DP-2-related protein is a novel DP-2 isoform that results from alternative splicing [5].
  • Although present at very different levels, DP-1 and DP-2 are evenly distributed among each of these complexes [6].
  • In humans, DP2 is preferentially expressed on type 2 lymphocytes, eosinophils, and basophils and mediates chemotaxis in vitro [2].

Biological context of TFDP2


Associations of TFDP2 with chemical compounds

  • PGD2 binds to two membrane receptors, D prostanoid receptor (DP)1 and DP2, endowed with antagonistic properties [2].
  • The second photoreaction process is photocyclization of cis-BSF, which occurs to give DP1 decaying with the half lifetime (tau1/2) of 2.8-4.0 micros to produce another DHP-type intermediate (DP2) with an absorption peak at 400 nm in the absence of O2, through [1,9]-hydrogen shift [10].
  • Based on metabolic studies of benzphetamine, we predicted the four major metabolites of BNMPA to be the N-demethyl compound, diphenyl-2-propanone (DP2P), p-hydroxy-N-demethyl BNMPA, and p-hydroxy-BNMPA [11].

Other interactions of TFDP2

  • In contrast, E2F-DP-2 exhibited little change in the preapoptotic cells [12].
  • E2F-6 is a nuclear protein that can form heterodimers with the DP proteins (both DP-I and DP-2) in vitro and in vivo [13].
  • 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils [14].

Analytical, diagnostic and therapeutic context of TFDP2


  1. Heterogeneous Cross-talk of E2F Family Members is Crucially Involved in Growth Modulatory Effects of Interferon-gamma and EGF. Reimer, D., Sadr, S., Wiedemair, A., Concin, N., Hofstetter, G., Marth, C., Zeimet, A.G. Cancer Biol. Ther. (2006) [Pubmed]
  2. Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. Spik, I., Brénuchon, C., Angéli, V., Staumont, D., Fleury, S., Capron, M., Trottein, F., Dombrowicz, D. J. Immunol. (2005) [Pubmed]
  3. Gene expression profiles of hepatoma cell line BEL-7402. Liu, L.X., Jiang, H.C., Liu, Z.H., Zhu, A.L., Zhou, J., Zhang, W.H., Wang, X.Q., Wu, M. Hepatogastroenterology (2003) [Pubmed]
  4. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Zheng, N., Fraenkel, E., Pabo, C.O., Pavletich, N.P. Genes Dev. (1999) [Pubmed]
  5. DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. Rogers, K.T., Higgins, P.D., Milla, M.M., Phillips, R.S., Horowitz, J.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Moberg, K., Starz, M.A., Lees, J.A. Mol. Cell. Biol. (1996) [Pubmed]
  7. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. Zhang, Y., Venkatraj, V.S., Fischer, S.G., Warburton, D., Chellappan, S.P. Genomics (1997) [Pubmed]
  8. Effect of naturally occurring E2F-4 alterations on transcriptional activation and proliferation in transfected cells. Takashima, H., Matsumoto, Y., Matsubara, N., Shirakawa, Y., Kawashima, R., Tanino, M., Ito, S., Isozaki, H., Ouchida, M., Meltzer, S.J., Shimizu, K., Tanaka, N. Lab. Invest. (2001) [Pubmed]
  9. Expression of cell cycle/growth regulator genes in human hepatocellular carcinoma and adjacent normal liver tissues. Liu, L.X., Jiang, H.C., Liu, Z.H., Zhu, A.L., Zhang, W.H., Wu, L.F., Zhou, J., Wang, X.Q., Wu, M. Oncol. Rep. (2003) [Pubmed]
  10. Dihydrophenanthrene-type intermediates during photoreaction of trans-4'-benzyl-5-styrylfuran. Samori, S., Hara, M., Ho, T.I., Tojo, S., Kawai, K., Endo, M., Fujitsuka, M., Majima, T. J. Org. Chem. (2005) [Pubmed]
  11. alpha-Benzyl-N-methylphenethylamine (BNMPA), an impurity of illicit methamphetamine synthesis: II. Metabolism and urinary excretion (human). Moore, K.A., Poklis, A. Journal of analytical toxicology. (1995) [Pubmed]
  12. Unbound E2F modulates TGF-beta1-induced apoptosis in HuH-7 cells. Fan, G., Ma, X., Kren, B.T., Steer, C.J. J. Cell. Sci. (2002) [Pubmed]
  13. E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Cartwright, P., Müller, H., Wagener, C., Holm, K., Helin, K. Oncogene (1998) [Pubmed]
  14. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. Monneret, G., Cossette, C., Gravel, S., Rokach, J., Powell, W.S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
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