Gene Review:
Rbl2 - retinoblastoma-like 2
Mus musculus
Synonyms:
130 kDa retinoblastoma-associated protein, PRB2, RBR-2, Rb2, Retinoblastoma-like protein 2, ...
- The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. Haigis, K., Sage, J., Glickman, J., Shafer, S., Jacks, T. J. Biol. Chem. (2006)
- Pocket protein p130/Rb2 is required for efficient herpes simplex virus type 1 gene expression and viral replication. Ehmann, G.L., Burnett, H.A., Bachenheimer, S.L. J. Virol. (2001)
- Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo. Howard, C.M., Claudio, P.P., Gallia, G.L., Gordon, J., Giordano, G.G., Hauck, W.W., Khalili, K., Giordano, A. J. Natl. Cancer Inst. (1998)
- Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Ruiz, S., Segrelles, C., Bravo, A., Santos, M., Perez, P., Leis, H., Jorcano, J.L., Paramio, J.M. Development (2003)
- Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Claudio, P.P., Howard, C.M., Pacilio, C., Cinti, C., Romano, G., Minimo, C., Maraldi, N.M., Minna, J.D., Gelbert, L., Leoncini, L., Tosi, G.M., Hicheli, P., Caputi, M., Giordano, G.G., Giordano, A. Cancer Res. (2000)
- Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3. Sakane, A., Manabe, S., Ishizaki, H., Tanaka-Okamoto, M., Kiyokage, E., Toida, K., Yoshida, T., Miyoshi, J., Kamiya, H., Takai, Y., Sasaki, T. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Dannenberg, J.H., Schuijff, L., Dekker, M., van der Valk, M., te Riele, H. Genes Dev. (2004)
- E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Rayman, J.B., Takahashi, Y., Indjeian, V.B., Dannenberg, J.H., Catchpole, S., Watson, R.J., te Riele, H., Dynlacht, B.D. Genes Dev. (2002)
- Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Sage, J., Mulligan, G.J., Attardi, L.D., Miller, A., Chen, S., Williams, B., Theodorou, E., Jacks, T. Genes Dev. (2000)
- pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Hurford, R.K., Cobrinik, D., Lee, M.H., Dyson, N. Genes Dev. (1997)
- Density-dependent growth inhibition of fibroblasts ectopically expressing p27(kip1). Zhang, X., Wharton, W., Donovan, M., Coppola, D., Croxton, R., Cress, W.D., Pledger, W.J. Mol. Biol. Cell (2000)
- Effect of repeated convulsive seizures on brain gamma-aminobutyric acid metabolism in three sublines of mice differing by their response to acoustic stimulations. Ciesielski, L., Simler, S., Clement, J., Mandel, P. J. Neurochem. (1987)
- Protective immunity induced by outer membrane proteins of Salmonella typhimurium in mice. Udhayakumar, V., Muthukkaruppan, V.R. Infect. Immun. (1987)
- Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. LeCouter, J.E., Kablar, B., Whyte, P.F., Ying, C., Rudnicki, M.A. Development (1998)
- The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts. Carnac, G., Fajas, L., L'honoré, A., Sardet, C., Lamb, N.J., Fernandez, A. Curr. Biol. (2000)
- Molecular cloning and developmental expression of mouse p130, a member of the retinoblastoma gene family. Chen, G., Guy, C.T., Chen, H.W., Hu, N., Lee, E.Y., Lee, W.H. J. Biol. Chem. (1996)
- FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest. Laplantine, E., Rossi, F., Sahni, M., Basilico, C., Cobrinik, D. J. Cell Biol. (2002)
- Dissecting functions of the retinoblastoma tumor suppressor and the related pocket proteins by integrating genetic, cell biology, and electrophoretic techniques. Hansen, K., Lukas, J., Holm, K., Kjerulff, A.A., Bartek, J. Electrophoresis (1999)
- Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb. MacLellan, W.R., Garcia, A., Oh, H., Frenkel, P., Jordan, M.C., Roos, K.P., Schneider, M.D. Mol. Cell. Biol. (2005)
- In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1. Chang, T.K., Chen, J., Benetton, S.A. Drug Metab. Dispos. (2002)
- Antinociceptive effects of ginsenosides injected intracerebroventricularly or intrathecally in substance P-induced pain model. Choi, S.S., Han, E.J., Han, K.J., Lee, H.K., Suh, H.W. Planta Med. (2003)
- Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Corbeil, H.B., Whyte, P., Branton, P.E. Oncogene (1995)
- E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress. Polager, S., Ginsberg, D. J. Biol. Chem. (2003)
- The COOH-terminal region of pRb2/p130 binds to histone deacetylase 1 (HDAC1), enhancing transcriptional repression of the E2F-dependent cyclin A promoter. Stiegler, P., De Luca, A., Bagella, L., Giordano, A. Cancer Res. (1998)
- Control of retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130. Hoshikawa, Y., Mori, A., Amimoto, K., Iwabe, K., Hatakeyama, M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. Collado, M., Medema, R.H., Garcia-Cao, I., Dubuisson, M.L., Barradas, M., Glassford, J., Rivas, C., Burgering, B.M., Serrano, M., Lam, E.W. J. Biol. Chem. (2000)
- Epithelial proliferation induces novel changes in APC expression. Umar, S., Wang, Y., Sellin, J.H. Oncogene (2005)
- In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. Cho, J.Y., Yoo, E.S., Baik, K.U., Park, M.H., Han, B.H. Planta Med. (2001)
- The RB-related gene Rb2/p130 in neuroblastoma differentiation and in B-myb promoter down-regulation. Raschellà, G., Tanno, B., Bonetto, F., Negroni, A., Claudio, P.P., Baldi, A., Amendola, R., Calabretta, B., Giordano, A., Paggi, M.G. Cell Death Differ. (1998)
- A unique domain of pRb2/p130 acts as an inhibitor of Cdk2 kinase activity. De Luca, A., MacLachlan, T.K., Bagella, L., Dean, C., Howard, C.M., Claudio, P.P., Baldi, A., Khalili, K., Giordano, A. J. Biol. Chem. (1997)
- Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted in the Fused toes mouse mutation. Lesche, R., Peetz, A., van der Hoeven, F., Rüther, U. Mamm. Genome (1997)
- The retinoblastoma gene family is differentially expressed during embryogenesis. Jiang, Z., Zacksenhaus, E., Gallie, B.L., Phillips, R.A. Oncogene (1997)
- p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mulligan, G.J., Wong, J., Jacks, T. Mol. Cell. Biol. (1998)
- Vascular ligation response is independent of p107: stressing the role of the related p130. Sindermann, J.R., Köbbert, C., Bauer, F., Skaletz-Rorowski, A., Hohage, H., Plenz, G., Breithardt, G., March, K.L. Am. J. Physiol. Heart Circ. Physiol. (2003)