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Gene Review

Asap2  -  ArfGAP with SH3 domain, ankyrin repeat and...

Mus musculus

Synonyms: 6530401G17Rik, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2, Ddef2, Development and differentiation-enhancing factor 2, Gm1523, ...
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Disease relevance of Ddef2

  • Pyelonephritis-associated P-pili (PAP) of Escherichia coli O6,H(-),K1(-),F12,haemolysin(-) were purified by salt precipitation and affinity chromatography using Synsorb P1 [1].
  • Caerulein-induced acute pancreatitis in mice that constitutively overexpress Reg/PAP genes [2].
  • Serum amylase, pancreatic water content (as a measure of edema), pancreatic myeloperoxidase activity, and Reg/PAP expression were quantified [2].
  • BACKGROUND: The cystic fibrosis (CF) mouse pancreas has constitutively elevated expression of the Reg/PAP cell stress genes (60-fold greater Reg3alpha, and 10-fold greater PAP/Reg3beta and Reg3gamma) [2].

High impact information on Ddef2

  • We found that when loxP sites flank in a direct orientation the transcription termination sequence (1.1 kb) of the T. brucei GPEET/PAG3 locus, CRE recombinase deletes this termination sequence, permitting transcription and subsequent expression of a downstream reporter gene for the green fluorescent protein (GFP) [3].
  • A monoclonal antibody (mAb) was produced by fusion of the PAI myeloma cell line with splenic lymphocytes from BALB/c mice immunised with the purified PAP [1].

Analytical, diagnostic and therapeutic context of Ddef2

  • The mAb reacted with PAP in both immunofluorescence and haemagglutination tests when 108 strains isolated from urine samples were tested; the two tests were in agreement for 202 of 204 strains isolated from faecal samples [1].


  1. Production and characterisation of monoclonal antibodies against pyelonephritis-associated P-pili of Escherichia coli. Miyata, H., Kataoka, S., Moriguchi, N., Yamamoto, T., Michibata, I., Kobayashi, T., Maki, S. Pediatr. Nephrol. (1994) [Pubmed]
  2. Caerulein-induced acute pancreatitis in mice that constitutively overexpress Reg/PAP genes. Norkina, O., Graf, R., Appenzeller, P., De Lisle, R.C. BMC gastroenterology [electronic resource]. (2006) [Pubmed]
  3. Trypanosoma brucei: a first-generation CRE-loxP site-specific recombination system. Barrett, B., LaCount, D.J., Donelson, J.E. Exp. Parasitol. (2004) [Pubmed]
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