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Gene Review:

Tagln2 - transgelin 2

Mus musculus

Synonyms: 2700094C18Rik, Kiaa0120, SM22-beta, SM22beta, Sm22B, ...

Zhang, J.C. et al., Eddleston, J. et al., Doudney, K. et al.

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High impact information on Tagln2

In addition, SM22beta is expressed at high levels in the bronchial epithelium and lung mesenchyme, gastrointestinal epithelial cells and in the cartilagenous and periosteal layer of bones [1].
During mouse embryonic development, the SM22beta gene is expressed in a temporally and spatially regulated pattern in the tunica media of arteries and veins, endocardium and compact layer of the myocardium, bronchial epithelium and mesenchyme of the lung, gastrointestinal epithelium and cartilaginous primordia [1].
Linkage analysis and physical mapping have previously localized the Lp locus to a region on mouse chromosome 1 defined by the markers D1Mit113-Tagln2 [2].

Other interactions of Tagln2

The Lp interval, between D1Mit113 and Tagln2, can be spanned by two nonchimeric overlapping YACs that define a physical distance of approximately 1 Mb [3].

References

SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expression. Zhang, J.C., Helmke, B.P., Shum, A., Du, K., Yu, W.W., Lu, M.M., Davies, P.F., Parmacek, M.S. Mech. Dev. (2002) [Pubmed]
Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. Doudney, K., Murdoch, J.N., Paternotte, C., Bentley, L., Gregory, S., Copp, A.J., Stanier, P. Genomics (2001) [Pubmed]
Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston, J., Murdoch, J.N., Copp, A.J., Stanier, P. Genomics (1999) [Pubmed]

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