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MeSH Review

Tunica Media

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Disease relevance of Tunica Media


High impact information on Tunica Media


Chemical compound and disease context of Tunica Media


Biological context of Tunica Media


Anatomical context of Tunica Media


Associations of Tunica Media with chemical compounds

  • When compared with WKY, prehypertensive SHR also exhibited increased cross-sectional quantities of arterial media and elevated amplitudes of RVR change in response to norepinephrine and renal nerve stimulation [23].
  • Thus, not only is the amount of EDRF released by acetylcholine reduced in the presence of atherosclerosis, the tunica media beneath the atheromatous plaque is also to some extent responsible for the superoxide-induced inactivation of EDRF [24].
  • Within 24 hours of injury, Pluronic-based release of c-myc antisense oligomers reduced mRNA levels in the tunica media 2.5-fold and immunocytochemical identification of c-myc expression by 98.8% [25].
  • Six of 32 fatty streaks (19%) contained cholesterol clefts, which were found in the musculo-elastic (deep) layer of the intima or in the tunica media [26].
  • There was a significant positive correlation between hyaluronic acid content of normal tunica media and duration of diabetes, but not between hyaluronic acid content and age [27].

Gene context of Tunica Media


Analytical, diagnostic and therapeutic context of Tunica Media


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  17. SM22beta encodes a lineage-restricted cytoskeletal protein with a unique developmentally regulated pattern of expression. Zhang, J.C., Helmke, B.P., Shum, A., Du, K., Yu, W.W., Lu, M.M., Davies, P.F., Parmacek, M.S. Mech. Dev. (2002) [Pubmed]
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  20. Intercellular contacts in the media of the thoracic aorta of rat fetuses treated with beta-aminopropionitrile. Sosa-Melgarejo, J.A., Berry, C.L. J. Pathol. (1991) [Pubmed]
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  28. Lack of vascular adventitial fibroblastic cells in tumour stroma of intestinal-type and solid-type gastric carcinomas. Nakayama, H., Enzan, H., Miyazaki, E., Kuroda, N., Toi, M., Hiroi, M., Yasui, W. J. Clin. Pathol. (2004) [Pubmed]
  29. Peptidergic innervation of the human gallbladder. el-Salhy, M., Stenling, R., Grimelius, L. Ups. J. Med. Sci. (1996) [Pubmed]
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  31. Aortic smooth muscle cells contain vimentin instead of desmin. Frank, E.D., Warren, L. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  32. Glucocorticoid resistance caused by reduced expression of the glucocorticoid receptor in cells from human vascular lesions. Bray, P.J., Du, B., Mejia, V.M., Hao, S.C., Deutsch, E., Fu, C., Wilson, R.C., Hanauske-Abel, H., McCaffrey, T.A. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  33. alpha8beta1 Integrin expression in the rat carotid artery: involvement in smooth muscle cell migration and neointima formation. Zargham, R., Thibault, G. Cardiovasc. Res. (2005) [Pubmed]
  34. Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation. Apitz-Castro, R., Badimon, J.J., Badimon, L. Thromb. Res. (1992) [Pubmed]
  35. Overexpression of hyaluronan in the tunica media promotes the development of atherosclerosis. Chai, S., Chai, Q., Danielsen, C.C., Hjorth, P., Nyengaard, J.R., Ledet, T., Yamaguchi, Y., Rasmussen, L.M., Wogensen, L. Circ. Res. (2005) [Pubmed]
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