Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TAGLN2 - transgelin 2

Homo sapiens

Synonyms: CDABP0035, Epididymis tissue protein Li 7e, HA1756, KIAA0120, SM22-alpha homolog, ...

Francés, R. et al., Nagase, T. et al., Hoffrogge, R. et al., Stanier, P. et al.

Stanier, Abu-Hayyeh, Murdoch, Eddleston, Copp,

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High impact information on TAGLN2

The localization of Tagln2 was also determined and was found to map between Fcgr2 and D1Mit149 on distal mouse chromosome 1 [1].
In contrast, levels of transgelin 2 RNA differed to a much lesser extent (3-fold) in the two B cell populations, so transgelin 2 is an example of a molecule whose subset-specific expression is more readily detected by proteomic than transcriptomic analyses [2].
B-1 cells express transgelin 2: Unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells [2].
This differentiation-associated expression pattern was validated by Western blot analysis for transgelin-2, proliferating cell nuclear antigen, as well as peroxiredoxin 1 and 4 [3].
Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 [4].

References

Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship. Stanier, P., Abu-Hayyeh, S., Murdoch, J.N., Eddleston, J., Copp, A.J. Genomics (1998) [Pubmed]
B-1 cells express transgelin 2: Unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells. Francés, R., Tumang, J.R., Kaku, H., Gurdak, S.M., Rothstein, T.L. Mol. Immunol. (2006) [Pubmed]
2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM). Hoffrogge, R., Mikkat, S., Scharf, C., Beyer, S., Christoph, H., Pahnke, J., Mix, E., Berth, M., Uhrmacher, A., Zubrzycki, I.Z., Miljan, E., Völker, U., Rolfs, A. Proteomics (2006) [Pubmed]
Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. Nagase, T., Miyajima, N., Tanaka, A., Sazuka, T., Seki, N., Sato, S., Tabata, S., Ishikawa, K., Kawarabayasi, Y., Kotani, H. DNA Res. (1995) [Pubmed]

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TAGLN2	Bos taurus
TAGLN2	Canis lupus familiaris
TAGLN2	Gallus gallus
TAGLN2	Macaca mulatta
Tagln2	Mus musculus
TAGLN2	Pan troglodytes
Tagln2	Rattus norvegicus
tagln2	Xenopus (Silurana) tropicalis

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