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Gene Review:

ALDH1B1 - aldehyde dehydrogenase 1 family, member B1

Homo sapiens

Synonyms: ALDH5, ALDHX, Aldehyde dehydrogenase 5, Aldehyde dehydrogenase X, mitochondrial, Aldehyde dehydrogenase family 1 member B1

Holmes, R.S. et al., Sherman, D.I. et al., Dockham, P.A. et al., Yoshida, A., Sherman, D. et al., et al.

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High impact information on ALDH1B1

The ALDH5 gene, which is expressed in testes and liver, is highly polymorphic in both Caucasians and Orientals [1].
Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13 [2].
ALDH-4, ALDH-5 and betaine aldehyde dehydrogenase did not catalyze the oxidation of either aldophosphamide or retinaldehyde [3].
PCR studies of the ALDH5 gene have demonstrated diverse polymorphism within a short segment of its coding region, with marked inter-racial variation in allele frequencies [4].

Anatomical context of ALDH1B1

Similarly, kidney ALDHs were distributed between the cytosol (ALDH5) and the mitochondrial fractions (ALDHs 2, 4, and 5), whereas a major isozyme (ALDH3), found in high activity in cornea, esophagus, ear pinna, tail, and stomach extracts, was localized predominantly in the cytosol fraction [5].

Associations of ALDH1B1 with chemical compounds

Human aldehyde dehydrogenase-5 gene (originally named as ALDHX) is expressed in liver and testis [6].

References

Molecular genetics of human aldehyde dehydrogenase. Yoshida, A. Pharmacogenetics (1992) [Pubmed]
Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13. Hiraoka, L.R., Hsu, L., Hsieh, C.L. Genomics (1995) [Pubmed]
Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. Dockham, P.A., Lee, M.O., Sladek, N.E. Biochem. Pharmacol. (1992) [Pubmed]
Alcohol and acetaldehyde dehydrogenase gene polymorphism and alcoholism. Sherman, D.I., Ward, R.J., Yoshida, A., Peters, T.J. EXS. (1994) [Pubmed]
Aldehyde dehydrogenase (ALDH) isozymes in the gray short-tailed opossum (Monodelphis domestica): tissue and subcellular distribution and biochemical genetics of ALDH3. Holmes, R.S., van Oorschot, R.A., VandeBerg, J.L. Biochem. Genet. (1991) [Pubmed]
Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene. Sherman, D., Davé, V., Hsu, L.C., Peters, T.J., Yoshida, A. Hum. Genet. (1993) [Pubmed]

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ALDH1B1	Bos taurus
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KLLA0F00440g	Kluyveromyces lactis NRRL Y-1140
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ALD4	Saccharomyces cerevisiae S288c
aldh1b1	Xenopus (Silurana) tropicalis

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